弥漫性恶性腹膜间皮瘤中的性别差异。
Sex difference in diffuse malignant peritoneal mesothelioma.
作者信息
Yan T D, Popa E, Brun E A, Cerruto C A, Sugarbaker P H
机构信息
Washington Cancer Institute, Washington, DC 20010, USA.
出版信息
Br J Surg. 2006 Dec;93(12):1536-42. doi: 10.1002/bjs.5377.
BACKGROUND
Diffuse malignant peritoneal mesothelioma (DMPM) is rare and in the past has proved an invariably fatal disease. Female patients have been reported to have an improved survival outcome for reasons that are not understood.
METHODS
The survival of 34 men and 28 women who underwent cytoreduction and perioperative intraperitoneal chemotherapy for DMPM was compared. Twenty-five clinicopathological variables were subjected to univariate analysis.
RESULTS
The women had a 5-year survival rate of 63 per cent and median survival was not reached. The men had a 5-year survival rate of 42 per cent, with a median survival of 32 months (P = 0.045). Women had undergone more extensive previous surgery and had less extensive peritoneal involvement at the time of cytoreduction. Tumours in women more frequently showed a small nuclear size (30 microm or less) and the chromatin pattern was more often granular than clear.
CONCLUSION
Women with DMPM had better survival. This observation may be related to the favourable clinical and histopathological features associated with women.
背景
弥漫性恶性腹膜间皮瘤（DMPM）较为罕见，过去一直被证明是一种致命性疾病。据报道，女性患者的生存结果有所改善，但其原因尚不清楚。
方法
比较了34例接受细胞减灭术和围手术期腹腔内化疗的DMPM男性患者和28例女性患者的生存情况。对25个临床病理变量进行单因素分析。
结果
女性患者的5年生存率为63%，中位生存期未达到。男性患者的5年生存率为42%，中位生存期为32个月（P = 0.045）。女性患者既往接受的手术范围更广，在进行细胞减灭术时腹膜受累范围较小。女性患者的肿瘤更常表现为小核大小（30微米或更小），染色质模式更常呈颗粒状而非清晰状。
结论
患有DMPM的女性生存情况更好。这一观察结果可能与女性相关的有利临床和组织病理学特征有关。
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