Zhang YanQi, Lil LinLin, Tang Fangqiong, Ren Jun
Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100080, PR China.
J Nanosci Nanotechnol. 2006 Sep-Oct;6(9-10):3210-4. doi: 10.1166/jnn.2006.469.
A novel controlled drug delivery system was fabricated by coating chitosan/PAA multilayer onto magnetic hollow spheres via a "Layer-by-Layer" (LBL) assembly approach. Cefradine was used as a model drug to evaluate the drug release characteristics of this core-shell hollow structure and the results show that it exhibits a sustained release of the drug and the release rate can be regulated by the pH environment of release medium. It is believed that this core-shell hollow structure, which combines the advantage of controlled delivery as well as magnetic targeting, has commendable potential in drug delivery therapeutics.
通过“逐层”（LBL）组装方法将壳聚糖/聚丙烯酸多层膜包覆在磁性空心球上，制备了一种新型的控释给药系统。以头孢拉定作为模型药物来评估这种核壳空心结构的药物释放特性，结果表明该结构呈现出药物的持续释放，并且释放速率可通过释放介质的pH环境进行调节。据信，这种结合了控释和磁靶向优势的核壳空心结构在药物递送治疗方面具有值得称赞的潜力。
