[蓝萼甲素对小鼠Th1/Th2型细胞因子水平的影响]
[Effect of glaucocalyxin A on level of Th1/Th2 type cytokines in mice].
作者信息
Chen Zi-jun, Li Yun-sen, Zhou Ji-yan, Wang Zheng-tao
机构信息
Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine.
出版信息
Zhongguo Zhong Yao Za Zhi. 2006 Aug;31(15):1257-60.
OBJECTIVE
To research the effect of glaucocalyxin A (GLA) on the level of Th1/Th2 type cytokines in mice.
METHOD
By using flow cytometer with CBA software to detect Th1/Th2 type cytokines.
RESULT
GLA had insighificant inhibitory effects on Th1 and Th2 cytokines (IL-2, IFN-gamma,TNF-alpha, IL-4 and IL-5) induced by ConA, in which more potential on cytokines from Th1 than those of from Th2 were displayed. However, GLA could produce inhibition on IL-2, IFN-gamma and TNF-alpha and acceleration on IL-4 and IL-5.
CONCLUSION
Immunosuppressive effect of GLA is related to the influence the level of Th1/Th2 type cytokines.
目的
研究蓝萼甲素（GLA）对小鼠Th1/Th2型细胞因子水平的影响。
方法
采用流式细胞仪结合CBA软件检测Th1/Th2型细胞因子。
结果
GLA对刀豆蛋白A诱导的Th1和Th2细胞因子（IL-2、IFN-γ、TNF-α、IL-4和IL-5）具有不显著的抑制作用，其中对Th1细胞因子的作用比对Th2细胞因子的作用更具潜力。然而，GLA可抑制IL-2、IFN-γ和TNF-α，并促进IL-4和IL-5。
结论
GLA的免疫抑制作用与对Th1/Th2型细胞因子水平的影响有关。
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