Mezquita J, Mezquita C
Department of Physiological Sciences, Faculty of Medicine, University of Barcelona, Casanova, Spain.
FEBS Lett. 1991 Feb 11;279(1):69-72. doi: 10.1016/0014-5793(91)80253-y.
We have previously reported that a chicken polyubiquitin gene (Ub II) not expressed under normal or heat shock conditions in chick fibroblasts is transcribed during spermatogenesis [(1987) Nucleic Acids Res. 15, 9604]. The level of Ub II mRNA is several-fold higher in testis cells than in somatic tissues. The gene Ub II possesses characteristic features not seen in the polyubiquitin gene expressed in heat shock conditions (Ub I). The 5' noncoding region of Ub II shows the consensus cAMP regulatory element (CRE) followed immediately downstream by a CA dinucleotide. It has been proposed that this extended CRE may be involved in the coordinate expression of various genes during spermatogenesis.
我们之前曾报道，鸡的一种多聚泛素基因（Ub II）在鸡成纤维细胞的正常或热休克条件下均不表达，但在精子发生过程中会被转录[(1987)核酸研究。15, 9604]。Ub II mRNA在睾丸细胞中的水平比在体细胞组织中高几倍。Ub II基因具有在热休克条件下表达的多聚泛素基因（Ub I）中未见的特征。Ub II的5'非编码区显示出一致的cAMP调节元件（CRE），紧接着其下游是一个CA二核苷酸。有人提出，这个扩展的CRE可能参与精子发生过程中各种基因的协同表达。
