Schindler A E
Zentrum für Frauenheilkunde, Universitätsklinikum Essen.
Geburtshilfe Frauenheilkd. 1990 Oct;50(10):749-53. doi: 10.1055/s-2008-1026359.
Besides the various androgenic activities actions in women, signs of androgenisation such as acne, seborrhoe, hirsutism and alopecia, play an important clinical role and require a proper diagnostic evaluation and individualised medical treatment. After development and thorough clinical evaluation of antiandrogen, a variety of therapeutic possibilities have become available. The main antiandrogens are: Cyproterone acetate, chlormadinone acetate and spironolactone. They are used in mono- or combination-therapy regimens. Means of application (oral, parenteral), dosages used and different forms of combination therapies are presented under practical aspects. The effects of such treatment modalities are outlined.
除了雄激素在女性体内的各种作用外,雄激素化的体征如痤疮、脂溢性皮炎、多毛症和脱发,在临床上具有重要意义,需要进行适当的诊断评估和个体化治疗。在抗雄激素药物研发并经过全面临床评估后,出现了多种治疗选择。主要的抗雄激素药物有:醋酸环丙孕酮、醋酸氯地孕酮和螺内酯。它们可用于单药治疗或联合治疗方案。本文从实际应用角度介绍了给药方式(口服、胃肠外给药)、使用剂量以及不同形式的联合治疗方法,并概述了这些治疗方式的效果。