Pugeat M
Hospices Civils de Lyon, Laboratoire de la Clinique Endocrinologique, Hôpital de l'Antiquaille.
Rev Fr Gynecol Obstet. 1989 Jun;84(6):505-8.
Several antiandrogens compounds are available in the treatment of acne and hirsutism in women. Cyproterone acetate is the most effective antiandrogen. Its use must prevent the occurrence of amenorrhea with the prescription of an appropriate estrogen. Spironolactone, less effective, is better tolerated on a long-term basis, if precaution is taken to combine it sequentially with a progesterone or a norprogesterone, in order to avoid the occurrence of short cycles. This is the treatment of choice of moderate hirsutism or acne, in young patients. The association of spironolactone with an estroprogestative without nortestosterone is easy to use and well tolerated, and gives good results on acne and hirsutism.
有几种抗雄激素化合物可用于治疗女性痤疮和多毛症。醋酸环丙孕酮是最有效的抗雄激素。使用时必须通过开具适当的雌激素来防止闭经的发生。螺内酯效果较差，但如果采取措施将其与孕激素或炔诺孕酮序贯联合使用以避免短周期的出现，则长期耐受性较好。这是年轻患者中度多毛症或痤疮的首选治疗方法。螺内酯与不含睾酮的雌孕激素联合使用易于操作且耐受性良好，对痤疮和多毛症效果良好。
