高效微波辅助合成胺取代的四（五氟苯基）卟啉
Efficient microwave-assisted synthesis of amine-substituted tetrakis(pentafluorophenyl)porphyrin.
作者信息
Samaroo Diana, Soll Clifford E, Todaro Louis J, Drain Charles M
机构信息
Department of Chemistry & Biochemistry, Hunter College and the Graduate Center of the City University of New York, 695 Park Avenue, New York, NY 10021, USA.
出版信息
Org Lett. 2006 Oct 26;8(22):4985-8. doi: 10.1021/ol060946z.
Abstract
We report an efficient and rapid means for the synthesis of tetrakis(pentafluorophenyl)porphyrin (TPPF(20)) derivatives by microwave irradiation in an environmentally acceptable solvent. The selective displacement of the para-fluorine groups in TPPF(20) by primary amines occurs in yields between 70 and 95%. This method demonstrates that TPPF(20) is an ideal platform for the rapid formation of porphyrin conjugates for therapeutic, catalytic, and other applications. [reaction: see text]
摘要
我们报道了一种在环境友好型溶剂中通过微波辐射高效快速合成四（五氟苯基）卟啉（TPPF(20)）衍生物的方法。伯胺对TPPF(20)中对氟基团的选择性取代反应产率在70%至95%之间。该方法表明，TPPF(20)是用于治疗、催化及其他应用的卟啉共轭物快速形成的理想平台。[反应：见正文]
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