Hadlock Tessa, Sundback Cathryn
Massachusetts Eye and Ear Infirmary and Harvard Medical School, Division of Facial Plastic and Reconstructive Surgery, 243 Charles St, Boston, MA 02114, USA.
Expert Opin Biol Ther. 2006 Nov;6(11):1105-11. doi: 10.1517/14712598.6.11.1105.
As the biological processes governing nerve regeneration have become elucidated over the past decades, interest has developed in manipulating these processes to improve nerve regeneration. Drug delivery to the regenerating nerve has the potential for major clinical applications in neurodegenerative diseases, spinal cord injury and peripheral nerve injury or sacrifice. This article reviews the evolution of the field of drug delivery to the regenerating nerve, from simple local applications of neurotrophic agents in solution and osmotic pump delivery, to the existing approaches involving novel biomaterials and genetically manipulated cell populations. A discussion of the various known nerve growth-promoting agents, and the chemical considerations involved in their delivery, is included. A perspective on the role of tissue engineering approaches for nerve regeneration in the future is offered.
在过去几十年中，随着控制神经再生的生物学过程逐渐被阐明，人们开始对操控这些过程以促进神经再生产生兴趣。向再生神经递送药物在神经退行性疾病、脊髓损伤以及周围神经损伤或牺牲方面具有重大临床应用潜力。本文回顾了向再生神经递送药物这一领域的发展历程，从神经营养因子在溶液中的简单局部应用和渗透泵递送，到涉及新型生物材料和基因操控细胞群体的现有方法。文中还讨论了各种已知的神经生长促进剂及其递送过程中涉及的化学因素。此外，还展望了组织工程方法在未来神经再生中的作用。
