Garg Sanjay K, Santucci Marilina B, Panitti Miriam, Pucillo Leo, Bocchino Marialuisa, Okajima Fumikazu, Bisen Prakash S, Saltini Cesare, Fraziano Maurizio
Department of Biology, University of Rome Tor Vergata Via della Ricerca Scientifica-00133, Rome, Italy.
Clin Immunol. 2006 Dec;121(3):260-4. doi: 10.1016/j.clim.2006.09.002. Epub 2006 Oct 16.
Sphingosine 1-phosphate (S1P) has recently been reported to induce antimycobacterial activity in vitro and in a mouse model of in vivo Mycobacterium tuberculosis infection. However, its role in the course of pulmonary tuberculosis in humans is still not known. This study shows that S1P levels in airway surface fluid of tuberculosis (TB) patients are significantly less than those observed in non-TB control patients. Moreover, the in vitro stimulation of bronchoalveolar lavage cells coming from TB patients with S1P significantly reduces intracellular growth of endogenous mycobacterial isolates. These results show that, in the course of pulmonary TB, airway epithelial fluid-associated S1P may play a protective role in the containment of intracellular mycobacterial growth and that its decrease may represent a novel pathogenic mechanism through which M. tuberculosis favors its replication.
鞘氨醇-1-磷酸（S1P）最近被报道在体外以及在小鼠体内结核分枝杆菌感染模型中具有诱导抗分枝杆菌活性的作用。然而，其在人类肺结核病程中的作用仍不清楚。本研究表明，肺结核（TB）患者气道表面液体中的S1P水平显著低于非TB对照患者。此外，用S1P体外刺激来自TB患者的支气管肺泡灌洗细胞可显著降低内源性分枝杆菌分离株的细胞内生长。这些结果表明，在肺结核病程中，气道上皮液体相关的S1P可能在抑制细胞内分枝杆菌生长中发挥保护作用，其水平降低可能代表结核分枝杆菌促进其复制的一种新的致病机制。
