鞘氨醇-1-磷酸信号传导影响淋巴细胞迁移、炎症和感染。
Sphingosine 1-phosphate signaling impacts lymphocyte migration, inflammation and infection.
作者信息
Tiper Irina V, East James E, Subrahmanyam Priyanka B, Webb Tonya J
机构信息
Department of Microbiology and Immunology, University of Maryland School of Medicine and the Marlene and Stewart Greenebaum Cancer Center, 685 W Baltimore St., Baltimore, MD 21201, USA.
Department of Microbiology and Immunology, University of Maryland School of Medicine and the Marlene and Stewart Greenebaum Cancer Center, 685 W Baltimore St., Baltimore, MD 21201, USA
出版信息
Pathog Dis. 2016 Aug;74(6). doi: 10.1093/femspd/ftw063. Epub 2016 Jun 27.
Abstract
Sphingosine 1-phosphate (S1P) is a sphingosine containing lipid intermediate obtained from ceramide. S1P is known to be an important signaling molecule and plays multiple roles in the context of immunity. This lysophospholipid binds and activates G-protein-coupled receptors (GPCRs) known as S1P receptors 1-5 (S1P1-5). Once activated, these GPCRs mediate signaling that can lead to alterations in cell proliferation, survival or migration, and can also have other effects such as promoting angiogenesis. In this review, we will present evidence demonstrating a role for S1P in lymphocyte migration, inflammation and infection, as well as in cancer. The therapeutic potential of targeting S1P receptors, kinases and lyase will also be discussed.
摘要
1-磷酸鞘氨醇（S1P）是一种源自神经酰胺的含鞘氨醇脂质中间体。已知S1P是一种重要的信号分子，在免疫方面发挥多种作用。这种溶血磷脂结合并激活称为S1P受体1-5（S1P1-5）的G蛋白偶联受体（GPCR）。一旦激活，这些GPCR介导的信号传导可导致细胞增殖、存活或迁移的改变，还可产生其他作用，如促进血管生成。在本综述中，我们将展示证据，证明S1P在淋巴细胞迁移、炎症和感染以及癌症中的作用。还将讨论靶向S1P受体、激酶和裂解酶的治疗潜力。
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