Is it possible to predict the long-term response to venlafaxine with the use of biological markers and psychophysiological methods?
作者信息
Fountoulakis K N, Iacovides A, Karamouzis M, Gerasimou G, Grammatikos Ph, Fotiou F, Kaprinis G
机构信息
Laboratory of Psychophysiology, 3rd Department of Psychiatry, Aristotle University of Thesssaloniki, Greece.
出版信息
J Affect Disord. 2007 Apr;99(1-3):155-63. doi: 10.1016/j.jad.2006.09.008. Epub 2006 Oct 16.
INTRODUCTION
The present study investigated whether it is possible to predict the medium term response to venlafaxine using biological markers and psychophysiological methods.
MATERIAL
Fourteen (14) patients aged 21-60 years suffering from Major Depression according to DSM-IV were included in the study.
METHODS
The SCAN v 2.0 and the IPDE were used to assist clinical diagnosis. Patients were investigated with electrooculogram (EOG), Pattern-Reversal Visual Evoked Potentials (PR-VEPs), Dexamethasone Suppression Test (DST), D-fenfluramine Challenge Test, and brain Single Photon Emission Tomography (SPECT). Venlafaxine 150-225 mg per os daily was administered. The follow-up period was 2 years.
STATISTICAL ANALYSIS
Chi-square test and ANOVA were used for the analysis of data.
RESULTS
There was a lower left globus pallidus regional cerebral blood flow in patients with better response. On the contrary, chronic patients were closer to normality.
DISCUSSION
The results of the current study provide preliminary evidence concerning our ability to predict response to venlafaxine and to understand its way of action.
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