Peter Klussmann Jens, Wittekindt Claus, Florian Preuss Simon, Al Attab Abdulrahman, Schroeder Ursula, Guntinas-Lichius Orlando
Department of Oto-Rhino-Laryngology, Head and Neck Surgery, University of Cologne, Cologne, Germany.
Acta Otolaryngol. 2006 Dec;126(11):1213-7. doi: 10.1080/00016480600740605.
We identified smoking as a significant risk factor for multilocular Warthin tumor development. Therefore, we recommend taking history of smoking into account when making the decisions for surgical strategy.
Warthin tumor is a common benign neoplasm of the parotid gland. Risk factors for multilocular development have not been defined.
A total of 185 consecutive patients treated for Warthin tumor were included. Charts were reviewed for symptoms, risk factors, and diagnostic and surgical procedures. Patients were followed for facial function and recurrence. Risk factors were evaluated.
Overall, in 203 parotid operations, a lateral parotidectomy (77%) was performed in most cases; 94% were primary surgery and 6% were revision surgery. In 89% of patients swelling was the only symptom. Bilateral Warthin tumor was seen in 17% of patients. Of these cases synchronous and metachronous bilateral tumors were observed in 61% and 39%, respectively. The median time period for second contralateral tumor development was 7 years. Postoperative transient facial dysfunction was observed in 31%, which recovered within 3 months in all cases. Evaluation of risk factors revealed that 89% of the subjects were smokers and 66% were heavy smokers. The risk for bilateral Warthin tumors correlated significantly with the amount of nicotine intake (p=0.003).
我们确定吸烟是多房性沃辛瘤发生的一个重要危险因素。因此，我们建议在制定手术策略时考虑吸烟史。
沃辛瘤是腮腺常见的良性肿瘤。多房性发展的危险因素尚未明确。
共纳入185例连续接受沃辛瘤治疗的患者。查阅病历以了解症状、危险因素以及诊断和手术过程。对患者进行面部功能和复发情况的随访。评估危险因素。
总体而言，在203例腮腺手术中，大多数病例（77%）进行了腮腺浅叶切除术；94%为初次手术，6%为翻修手术。89%的患者肿胀是唯一症状。17%的患者出现双侧沃辛瘤。在这些病例中，分别有61%和39%观察到双侧肿瘤同时发生和异时发生。对侧第二个肿瘤发生的中位时间为7年。31%的患者术后出现短暂性面部功能障碍，所有病例均在3个月内恢复。危险因素评估显示，89%的受试者为吸烟者，66%为重度吸烟者。双侧沃辛瘤的风险与尼古丁摄入量显著相关（p = 0.003）。
