Leikola J P, Leppänen E A, von Smitten K A J, Leidenius M H K
Breast Surgery Unit, Maria Hospital, Helsinki, Finland.
Acta Radiol. 2006 Oct;47(8):760-3. doi: 10.1080/02841850600830654.
To evaluate the influence of a second radioisotope injection on the intraoperative success rate in patients with non-visualized axillary sentinel nodes (SN).
Altogether, 534 consecutive breast cancer patients with lymphoscintigraphy (LS) and SN biopsy and were included. An intratumoral injection of 99mTc-labeled human albumin colloid with a median dose of 93 MBq was applied. Forty-two of the 80 patients without axillary hot spots on LS received a second tracer injection with a median dose of 70 MBq.
The visualization rate of axillary SN was 454/534 (85%). The intraoperative SN identification rate was 97% in patients with and 69% in patients without visualized SN in the axilla (P<0.00005), but the success rate was higher (88%) with a second radioisotope injection than without it (47%; P<0.0002).
The failure rate in intraoperative SN identification was minimized using a second radioisotope injection in patients without axillary SN on LS.
评估第二次放射性同位素注射对腋窝前哨淋巴结（SN）未显影患者术中成功率的影响。
共纳入534例连续接受淋巴闪烁显像（LS）和前哨淋巴结活检的乳腺癌患者。瘤内注射99mTc标记的人白蛋白胶体，中位剂量为93MBq。80例LS检查腋窝无热点的患者中有42例接受了第二次示踪剂注射，中位剂量为70MBq。
腋窝前哨淋巴结的显影率为454/534（85%）。腋窝前哨淋巴结显影的患者术中前哨淋巴结识别率为97%，腋窝前哨淋巴结未显影的患者为69%（P<0.00005），但第二次放射性同位素注射的成功率（88%）高于未注射的成功率（47%；P<0.0002）。
对于LS检查腋窝前哨淋巴结未显影的患者，使用第二次放射性同位素注射可将术中前哨淋巴结识别的失败率降至最低。
