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皮质神经元的早期表型表达：迁移神经元亚类具有胼胝体轴突的证据。

Early phenotype expression of cortical neurons: evidence that a subclass of migrating neurons have callosal axons.

作者信息

Schwartz M L, Rakic P, Goldman-Rakic P S

机构信息

Section of Neuroanatomy, Yale University School of Medicine, New Haven, CT 06510.

出版信息

Proc Natl Acad Sci U S A. 1991 Feb 15;88(4):1354-8. doi: 10.1073/pnas.88.4.1354.

DOI:10.1073/pnas.88.4.1354
PMID:1705036
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC51016/
Abstract

The use of [3H]thymidine labeling in combination with various axonal transport tracers has revealed that a subset of migrating neurons in the fetal monkey cerebrum issue axons to the opposite cerebral hemisphere while still migrating to their final positions in the cortical plate. Other cortical neurons with the same "birthdate" (i.e., that underwent their last round of DNA synthesis on the same day) are not retrogradely labeled by tracer injections of the opposite hemisphere. These findings suggest that the cardinal distinction between projection and local circuit neurons may be specified in postmitotic neurons before they acquire their final positions in the cortex.

摘要

将[3H]胸腺嘧啶核苷标记与各种轴突运输示踪剂相结合的研究表明，胎猴大脑中一部分正在迁移的神经元在仍向皮质板中的最终位置迁移时，就已向对侧大脑半球发出轴突。其他具有相同“出生日期”（即在同一天进行最后一轮DNA合成）的皮质神经元，不会因对侧半球的示踪剂注射而被逆行标记。这些发现表明，投射神经元和局部回路神经元之间的主要区别可能在有丝分裂后的神经元获得其在皮质中的最终位置之前就已确定。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e38/51016/380c4dc2d999/pnas01054-0282-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e38/51016/20e36a6a28b4/pnas01054-0280-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e38/51016/565103caede3/pnas01054-0280-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e38/51016/236f637341f3/pnas01054-0281-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e38/51016/380c4dc2d999/pnas01054-0282-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e38/51016/20e36a6a28b4/pnas01054-0280-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e38/51016/565103caede3/pnas01054-0280-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e38/51016/236f637341f3/pnas01054-0281-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e38/51016/380c4dc2d999/pnas01054-0282-a.jpg

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