van Brussel Marco, Takken Tim, van der Net Janjaap, Engelbert Raoul H H, Bierings Marc, Schoenmakers Marja A G C, Helders Paul J M
Department of Paediatric Physical Therapy & Exercise Physiology, University Hospital for Children and Youth Wilhelmina Kinderziekenhuis, University Medical Center Utrecht, Utrecht, The Netherlands.
Pediatr Rehabil. 2006 Jul-Sep;9(3):267-74. doi: 10.1080/13638490500523150.
To evaluate the physical function and fitness in survivors of childhood leukaemia 5-6 years after cessation of chemotherapy.
Thirteen children (six boys and seven girls; mean age 15.5 years) who were treated for leukaemia were studied 5-6 years after cessation of therapy. Physical function and fitness were determined by anthropometry, motor performance, muscle strength, anaerobic and aerobic exercise capacity.
On motor performance, seven of the 13 patients showed significant problems in the hand-eye co-ordination domain. Muscle strength only showed a significantly lower value in the mean strength of the knee extensors. The aerobic and the anaerobic capacity were both significantly reduced compared to reference values.
Even 5-6 years after cessation of childhood leukaemia treatment, there are still clear late effects on motor performance and physical fitness. Chemotherapy-induced neuropathy and muscle atrophies are probably the prominent cause for these reduced test results. Physical training might be indicated for patients surviving leukaemia to improve fitness levels and muscle strength.
评估化疗结束5至6年后儿童白血病幸存者的身体功能和健康状况。
对13名曾接受白血病治疗的儿童（6名男孩和7名女孩；平均年龄15.5岁）在治疗结束5至6年后进行研究。通过人体测量、运动表现、肌肉力量、无氧和有氧运动能力来确定身体功能和健康状况。
在运动表现方面，13名患者中有7名在手眼协调领域存在显著问题。肌肉力量仅在膝伸肌的平均力量方面显示出显著较低的值。与参考值相比，有氧和无氧能力均显著降低。
即使在儿童白血病治疗结束5至6年后，对运动表现和身体健康仍有明显的晚期影响。化疗引起的神经病变和肌肉萎缩可能是这些测试结果降低的主要原因。对于白血病幸存者，可能需要进行体育锻炼以提高健康水平和肌肉力量。
