Claus Elizabeth B, Petruzella Stacey, Carter Darryl, Kasl Stanislav
Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06520-8034, USA.
J Clin Oncol. 2006 Oct 20;24(30):4875-81. doi: 10.1200/JCO.2005.05.2290.
Limited data exist on long-term quality of life (QOL) for women diagnosed with breast carcinoma in situ (BCIS).
The data are on 795 BCIS participants diagnosed among female residents of Connecticut from September 15, 1994 to March 14, 1998, and 702 controls frequency-matched to the case participants by 5-year age intervals and geography. These women were participants in a large, population-based case/control study and subsequent follow-up study. Telephone interviews at follow-up were used to collect data on QOL at 5 years from initial diagnosis or contact, using the Medical Outcomes Study, Center for Epidemiologic Studies-Depression, and CAGE (Cut down, Annoyed, Guilty, Eye-opener) alcohol consumption scales. QOL outcomes were compared by case/control status and by case treatment group: lumpectomy, lumpectomy with adjuvant radiation therapy, and mastectomy.
At 5 years after diagnosis, women diagnosed with BCIS report levels of physical, emotional, and mental health functioning similar with those reported in a general healthy female population. Case participants and controls did not differ in reported levels of limitations due to physical health problems, bodily pain, social functioning, or overall physical functioning. Case participants who underwent lumpectomy with radiation reported lower levels of emotional functioning, general health perceptions, vitality, sexual interest, and overall mental health, as well as more depressive symptoms than did control subjects; although, the clinical significance of these statistical differences appears to be limited.
At 5 years after treatment, women diagnosed with BCIS report good physical and emotional functioning relative to control populations.
关于原位乳腺癌（BCIS）女性患者的长期生活质量（QOL）的数据有限。
数据来自1994年9月15日至1998年3月14日在康涅狄格州女性居民中诊断出的795例BCIS参与者，以及702名对照者，这些对照者按5岁年龄间隔和地理位置与病例参与者进行频率匹配。这些女性参与了一项大型的基于人群的病例/对照研究及后续随访研究。随访时通过电话访谈收集自初次诊断或接触起5年时的生活质量数据，使用医学结局研究量表、流行病学研究中心抑郁量表以及CAGE（减少饮酒量、烦恼、内疚、警醒）酒精消耗量表。按病例/对照状态以及病例治疗组（乳房肿瘤切除术、辅助放疗的乳房肿瘤切除术和乳房切除术）比较生活质量结果。
诊断后5年，被诊断为BCIS的女性报告的身体、情感和心理健康功能水平与一般健康女性人群报告的水平相似。病例参与者和对照者在因身体健康问题、身体疼痛、社会功能或总体身体功能导致的受限水平报告上没有差异。接受放疗的乳房肿瘤切除术的病例参与者比对照者报告的情感功能、总体健康感知、活力、性兴趣和总体心理健康水平更低，且抑郁症状更多；不过，这些统计学差异的临床意义似乎有限。
治疗后5年，被诊断为BCIS的女性相对于对照人群报告了良好的身体和情感功能。
