Hodr R, Stroufová A, Kepertová M, Ondrácková Z, Skutilová J
Ustav pro péci o matku a dítĕ, Praha.
Cesk Pediatr. 1990 Jul;45(7):390-3.
In a group of 154 mature normal neonates the authors recorded significantly higher mean alpha-fetoprotein values in children with hyperbilirubinaemia (higher than 205 mumol/l) than in other neonates. The differences were observed also in children of equal gestation age. Development of hyperbilirubinaemia is more probable and indication for phototherapy is significantly higher in neonates with alpha-fetoprotein levels in umbilical blood above 100 mg/l and these infants must be carefully observed. When the concentration is above 130 mg/l, the development of hyperbilirubinaemia may be assumed with certainty. Examination of alpha-fetoprotein in umbilical blood is an useful indicator of the functional maturity of the liver, but does not ensure reliable prediction of hyperbilirubinaemia in individual neonates. A concentration of alpha-fetoprotein above 100 mg/l is exceptional among neonates without hyperbilirubinaemia, while lower values do not rule out the development of hyperbilirubinaemia.
在一组154名成熟正常新生儿中，作者记录到，患有高胆红素血症（高于205μmol/l）的儿童其甲胎蛋白平均水平显著高于其他新生儿。在孕周相同的儿童中也观察到了这种差异。脐血中甲胎蛋白水平高于100mg/l的新生儿发生高胆红素血症的可能性更大，光疗指征也显著更高，必须对这些婴儿进行仔细观察。当浓度高于130mg/l时，可以确定会发生高胆红素血症。检测脐血中甲胎蛋白是肝脏功能成熟度的一个有用指标，但不能确保对个体新生儿高胆红素血症进行可靠预测。在没有高胆红素血症的新生儿中，甲胎蛋白浓度高于100mg/l的情况很罕见，而较低的值并不能排除高胆红素血症的发生。
