Malan C, Donald P R, Odendaal H J, Shanley B C
S Afr Med J. 1978 Aug 12;54(7):281-3.
The relationshop between the concentration of alpha1-fetoprotein (AFP) in cord blood and neonatal jaundice has been examined in 259 neonates. Cord blood AFP varies inversely with gestational age, as does the incidence of severe jaundice. Among babies born at term a higher mean AFP concentration in cord blood was found in the group which subsequently developed marked hyperbilirubinaemia. On average, the full-term babies with a cord blood AFP level above 130 mg/l developed more pronounced jaundice than the rest. We conclude that cord blood AFP concentrations reflect the maturity of the liver in both premature and full-term infants. It is a better criterion than the estimation of gestational period by physical examination of the baby.
对259例新生儿的脐带血甲胎蛋白（AFP）浓度与新生儿黄疸之间的关系进行了研究。脐带血AFP与胎龄呈反比，严重黄疸的发生率也如此。在足月出生的婴儿中，随后发生明显高胆红素血症的组中脐带血AFP平均浓度较高。平均而言，脐带血AFP水平高于130mg/l的足月儿比其他婴儿出现更明显的黄疸。我们得出结论，脐带血AFP浓度反映了早产儿和足月儿肝脏的成熟度。它比通过对婴儿进行体格检查来估计妊娠期是更好的标准。
