文献检索文档翻译深度研究
Suppr Zotero 插件Zotero 插件
邀请有礼套餐&价格历史记录

新学期，新优惠

限时优惠:9月1日-9月22日

30天高级会员仅需29元

1天体验卡首发特惠仅需5.99元

了解详情
不再提醒
插件&应用
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
高级版
套餐订阅购买积分包
AI 工具
文献检索文档翻译深度研究
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2025

Inhibitors of the catalytic domain of mitochondrial ATP synthase.

作者信息

Gledhill J R, Walker J E

机构信息

MRC Dunn Human Nutrition Unit, Wellcome Trust/MRC Building, Hills Road, Cambridge CB2 2XY, UK.

出版信息

Biochem Soc Trans. 2006 Nov;34(Pt 5):989-92. doi: 10.1042/BST0340989.

DOI:10.1042/BST0340989
PMID:17052243
Abstract

An understanding of the mechanism of ATP synthase requires an explanation of how inhibitors act. The catalytic F1-ATPase domain of the enzyme has been studied extensively by X-ray crystallography in a variety of inhibited states. Four independent inhibitory sites have been identified by high-resolution structural studies. They are the catalytic site, and the binding sites for the antibiotics aurovertin and efrapeptin and for the natural inhibitor protein, IF1.

摘要

相似文献

[1]
Inhibitors of the catalytic domain of mitochondrial ATP synthase.

Biochem Soc Trans. 2006-11

[2]
Inhibition sites in F1-ATPase from bovine heart mitochondria.

Biochem J. 2005-3-15

[3]
Significance of αThr-349 in the catalytic sites of Escherichia coli ATP synthase.

Biochemistry. 2014-12-2

[4]
Linking structural features from mitochondrial and bacterial F-type ATP synthases to their distinct mechanisms of ATPase inhibition.

Prog Biophys Mol Biol. 2015-10

[5]
Effects of the inhibitors azide, dicyclohexylcarbodiimide, and aurovertin on nucleotide binding to the three F1-ATPase catalytic sites measured using specific tryptophan probes.

J Biol Chem. 1998-12-11

[6]
Reversible optical control of F F -ATP synthase using photoswitchable inhibitors.

FEBS Lett. 2018-2-1

[7]
Cross-linking of the endogenous inhibitor protein (IF1) with rotor (gamma, epsilon) and stator (alpha) subunits of the mitochondrial ATP synthase.

J Bioenerg Biomembr. 2002-12

[8]
Cryo-EM structure of the mammalian ATP synthase tetramer bound with inhibitory protein IF1.

Science. 2019-6-14

[9]
Energetic signalling in the control of mitochondrial F1F0 ATP synthase activity in health and disease.

Int J Biochem Cell Biol. 2008

[10]
Unidirectional regulation of the FF-ATP synthase nanomotor by the ζ pawl-ratchet inhibitor protein of Paracoccus denitrificans and related α-proteobacteria.

Biochim Biophys Acta Bioenerg. 2018-6-8

引用本文的文献

[1]
Engineering of IF -susceptive bacterial F -ATPase.

Protein Sci. 2024-4

[2]
Apoptolidin family glycomacrolides target leukemia through inhibition of ATP synthase.

Nat Chem Biol. 2022-4

[3]
Reversible optical control of F F -ATP synthase using photoswitchable inhibitors.

FEBS Lett. 2018-2-1

[4]
Establishing the Secondary Metabolite Profile of the Marine Fungus: Tolypocladium geodes sp. MF458 and Subsequent Optimisation of Bioactive Secondary Metabolite Production.

Mar Drugs. 2017-3-23

[5]
Respiratory chain protein turnover rates in mice are highly heterogeneous but strikingly conserved across tissues, ages, and treatments.

FASEB J. 2015-8

[6]
Mitochondria from anoxia-tolerant animals reveal common strategies to survive without oxygen.

J Comp Physiol B. 2014-4

[7]
Downregulation of the δ-subunit reduces mitochondrial ATP synthase levels, alters respiration, and restricts growth and gametophyte development in Arabidopsis.

Plant Cell. 2012-7-17

[8]
ATP synthase: from single molecule to human bioenergetics.

Proc Jpn Acad Ser B Phys Biol Sci. 2010

[9]
F1F0-ATP synthases of alkaliphilic bacteria: lessons from their adaptations.

Biochim Biophys Acta. 2010-8

[10]
The effect of NBD-Cl in nucleotide-binding of the major subunit alpha and B of the motor proteins F1FO ATP synthase and A1AO ATP synthase.

J Bioenerg Biomembr. 2010-1-16

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

推荐工具

医学文档翻译智能文献检索