T细胞对T细胞的杀伤作用由特定表位诱导：凋亡机制的证据。
T cell-T cell killing is induced by specific epitopes: evidence for an apoptotic mechanism.
作者信息
Moss D J, Burrows S R, Baxter G D, Lavin M F
机构信息
Queensland Institute of Medical Research, Herston, Brisbane, Australia.
出版信息
J Exp Med. 1991 Mar 1;173(3):681-6. doi: 10.1084/jem.173.3.681.
Abstract
Epstein-Barr virus-specific cytotoxic T lymphocyte clones were shown to be an effective target for their own lysis when incubated in the presence of their specific epitopes but not in the presence of irrelevant epitopes. The mode of cell killing appeared to be by apoptosis and was prevented by previously described inhibitors of the process. Degranulation, as measured by serine esterase activity, was involved in this form of T cell-T cell killing. This is the first report of T cell-T cell killing by apoptosis and is only observed in the presence of a specific epitope. This result may be of significance in the use of peptide-based vaccines.
摘要
当在其特异性表位存在的情况下孵育时，爱泼斯坦-巴尔病毒特异性细胞毒性T淋巴细胞克隆被证明是自身裂解的有效靶点，但在无关表位存在时则不然。细胞杀伤模式似乎是通过凋亡，并且被先前描述的该过程抑制剂所阻止。通过丝氨酸酯酶活性测量的脱颗粒参与了这种形式的T细胞-T细胞杀伤。这是关于T细胞-T细胞通过凋亡进行杀伤的首次报道，并且仅在特异性表位存在时观察到。该结果可能在基于肽的疫苗的使用中具有重要意义。
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