Visavadiya Nishant P, Narasimhacharya Amaravadi V R L
Department of Biosciences, Sardar Patel University, Vallabh Vidyanagar, Gujarat, India.
Mol Nutr Food Res. 2006 Nov;50(11):1080-6. doi: 10.1002/mnfr.200600063.
The hypocholesterolaemic and antioxidant effects of Glycyrrhiza glabra (GG) root powder were examined in hypercholesterolaemic male albino rats. A 4-week administration of GG root powder (5 and 10 gm% in diet) to hypercholesterolaemic rats resulted in significant reduction in plasma, hepatic total lipids, cholesterol, triglycerides and plasma low-density lipoprotein and VLDL-cholesterol accompanied by significant increases in HDL-cholesterol levels. Furthermore, significant increases in fecal cholesterol, neutral sterols and bile acid excretion along with an increase in hepatic HMG-CoA reductase activity and bile acid production were observed in these animals. The root powder administration to hypercholesterolaemic rats also decreased hepatic lipid peroxidation with a concomitant increase in superoxide dismutase (SOD) and catalase activities and total ascorbic acid content. Thus, the hypocholesterolaemic and antioxidant effects of GG root appeared to be mediated via (i) accelerated cholesterol, neutral sterol and bile acid elimination through fecal matter with an increased hepatic bile acid production and (ii) improving the activities of hepatic SOD, catalase and increasing the ascorbic acid content. The normo-cholesterolaemic animals when fed with GG root powder at 10 gm% level, registered a significant decline in plasma lipid profiles and an increase in HDL-cholesterol content. The antioxidant status of these animals also was improved upon treatment.
在高胆固醇血症雄性白化大鼠中研究了光果甘草（GG）根粉的降胆固醇和抗氧化作用。给高胆固醇血症大鼠连续4周投喂GG根粉（饲料中含量为5%和10%），导致血浆、肝脏总脂质、胆固醇、甘油三酯以及血浆低密度脂蛋白和极低密度脂蛋白胆固醇显著降低，同时高密度脂蛋白胆固醇水平显著升高。此外，这些动物的粪便胆固醇、中性固醇和胆汁酸排泄显著增加，同时肝脏羟甲基戊二酰辅酶A还原酶活性和胆汁酸生成增加。给高胆固醇血症大鼠投喂根粉还降低了肝脏脂质过氧化，同时超氧化物歧化酶（SOD）和过氧化氢酶活性以及总抗坏血酸含量增加。因此，GG根的降胆固醇和抗氧化作用似乎是通过以下方式介导的：（i）通过粪便加速胆固醇、中性固醇和胆汁酸的消除，同时增加肝脏胆汁酸生成；（ii）提高肝脏SOD、过氧化氢酶的活性并增加抗坏血酸含量。正常胆固醇血症动物在投喂10%水平的GG根粉时，血浆脂质谱显著下降，高密度脂蛋白胆固醇含量增加。这些动物经治疗后抗氧化状态也得到改善。
