Lan Tao-Hua, Zhang Lu-Lu, Wang Yong-Hua, Wu Huan-Lin, Xu Dan-Ping
Department of Cardiology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510020, China.
Center of Bioinformatics, College of Life Science, Northwest A&F University, Yangling, Shaanxi 712100, China.
Evid Based Complement Alternat Med. 2018 May 10;2018:5170854. doi: 10.1155/2018/5170854. eCollection 2018.
Cardiovascular diseases (CVDs) have been recognized as first killer of human health. The underlying mechanisms of CVDs are extremely complicated and not fully revealed, leading to a challenge for CVDs treatment in modern medicine. Traditional Chinese medicine (TCM) characterized by multiple compounds and targets has shown its marked effects on CVDs therapy. However, system-level understanding of the molecular mechanisms is still ambiguous. In this study, a system pharmacology approach was developed to reveal the underlying molecular mechanisms of a clinically effective herb formula (Wen-Dan Decoction) in treating CVDs. 127 potential active compounds and their corresponding 283 direct targets were identified in Wen-Dan Decoction. The networks among active compounds, targets, and diseases were built to reveal the pharmacological mechanisms of Wen-Dan Decoction. A "CVDs pathway" consisted of several regulatory modules participating in therapeutic effects of Wen-Dan Decoction in CVDs. All the data demonstrates that Wen-Dan Decoction has multiscale beneficial activity in CVDs treatment, which provides a new way for uncovering the molecular mechanisms and new evidence for clinical application of Wen-Dan Decoction in cardiovascular disease.
心血管疾病（CVDs）已被公认为人类健康的头号杀手。心血管疾病的潜在机制极其复杂，尚未完全揭示，这给现代医学中心血管疾病的治疗带来了挑战。以多种化合物和靶点为特征的中药在心血管疾病治疗中显示出显著疗效。然而，对其分子机制的系统层面理解仍不明确。在本研究中，开发了一种系统药理学方法来揭示一种临床有效中药方剂（温胆汤）治疗心血管疾病的潜在分子机制。在温胆汤中鉴定出127种潜在活性化合物及其相应的283个直接靶点。构建了活性化合物、靶点和疾病之间的网络，以揭示温胆汤的药理机制。一条“心血管疾病通路”由几个参与温胆汤治疗心血管疾病疗效的调控模块组成。所有数据表明，温胆汤在心血管疾病治疗中具有多尺度有益活性，这为揭示分子机制提供了新途径，也为温胆汤在心血管疾病临床应用中提供了新证据。
