Mitsias D I, Kapsogeorgou E K, Moutsopoulos H M
Department of Pathophysiology, School of Medicine, National University of Athens, Athens, Greece.
Oral Dis. 2006 Nov;12(6):523-32. doi: 10.1111/j.1601-0825.2006.01292.x.
The expression 'autoimmune epithelitis' has been proposed as an alternative for Sjögren's syndrome (SS) based on data pointing out the central role of the epithelial cell in the pathogenesis of the syndrome. Clinically, apart from exocrine glands that are the main target, the epithelial component of the other organs such as kidneys, liver, lungs or thyroid is commonly affected resulting in various extraglandular manifestations. On the other hand, at the molecular and cellular level, the epithelial cell plays a major role in the initiation and perpetuation of the autoimmune lesion. Mechanisms such as antigen presentation, apoptosis, chemokine production or germinal center formation lie in the center of SS pathogenesis and the epithelial cell has a very important role. Herein, we present both aspects, review the data that support the proposed terminology and finally, suggest a unifying theory for the pathogenesis of SS.
基于指出上皮细胞在该综合征发病机制中核心作用的数据，“自身免疫性上皮炎”这一表述已被提议作为干燥综合征（SS）的替代名称。临床上，除了作为主要靶器官的外分泌腺外，肾脏、肝脏、肺或甲状腺等其他器官的上皮成分也常受影响，从而导致各种腺外表现。另一方面，在分子和细胞水平上，上皮细胞在自身免疫性病变的起始和持续过程中起主要作用。诸如抗原呈递、细胞凋亡、趋化因子产生或生发中心形成等机制是干燥综合征发病机制的核心，上皮细胞在其中起着非常重要的作用。在此，我们阐述这两个方面，回顾支持所提议术语的数据，最后提出一个关于干燥综合征发病机制的统一理论。
