维生素D与肾脏

Vitamin d and the kidney.

作者信息

Hill L F, Stanbury S W

出版信息

Nephron. 1975;15(3-5):369-86. doi: 10.1159/000180521.

Abstract

The biologically active form of vitamin D3, 1,25-dihydroxycholecalciferol is produced by the kidney. The biosynthesis of 1,25-dihydroxycholecalciferol from 25-hydroxycholecalciferol is apparently controlled and important factors in this control are dietary calcium and phosphorus, and parathyroid hormone secretion. The direct effects of vitamin D and its metabolites on renal function are uncertain. Patients with chronic renal failure have defective synthesis of 1,25-dihydroxycholecalciferol. Uremic patients treated with small doses of 1,25-dihydroxycholecalciferol or 1 alpha-hydroxycholecalciferol show increased intestinal calcium absorption and bone healing.

摘要

维生素D3的生物活性形式1,25 - 二羟胆钙化醇由肾脏产生。从25 - 羟胆钙化醇生物合成1,25 - 二羟胆钙化醇显然受到调控，而饮食中的钙和磷以及甲状旁腺激素分泌是这种调控的重要因素。维生素D及其代谢产物对肾功能的直接影响尚不确定。慢性肾衰竭患者合成1,25 - 二羟胆钙化醇存在缺陷。用小剂量的1,25 - 二羟胆钙化醇或1α - 羟胆钙化醇治疗的尿毒症患者肠道钙吸收增加，骨愈合改善。