一些对皮质酮分泌产生抑制作用的边缘系统结构之间的相互作用。

Interaction of some limbic structures which exert inhibitory effect on corticosterone secretion.

作者信息

Suárez M, Perassi N I

机构信息

Cátedra de Anatomía y Fisiología Humana, Facultad de Ciencias Exactas, Físicas y Naturales, Universidad Nacional de Córdoba, Argentina.

出版信息

Arch Int Physiol Biochim. 1990 Dec;98(6):325-9. doi: 10.3109/13813459009113993.

DOI:10.3109/13813459009113993

PMID:1705770

Abstract

The interaction between limbic structures which exert inhibitory influence on corticosterone secretion was investigated in the rat. The following experiments were performed: 1) electrical stimulation at mammillary medial nucleus (MMN) in rats with lesioned anterodrosal thalami nucleus (ADTN) or intermediate tegmental area; 2) electrical stimulation at ADTN in rats with lesioned retrosplenial cortex (RC). Bilateral stimulation at MMN in ADTN or RC-lesioned rats produces an increase in plasma corticosterone concentration. In animals with lesioned RC, values of plasma corticosterone after stimulation at ADTN were higher than before stimulation. Taking into consideration that electrical stimulation of MMN or ADTN in intact rats produces a decrease in plasma corticosterone concentration, these studies demonstrate that MMN and ADTN exert inhibitory influence on corticoadrenal activity only when their projection areas remain intact.

摘要

在大鼠中研究了对皮质酮分泌产生抑制作用的边缘系统结构之间的相互作用。进行了以下实验：1）对前背侧丘脑核（ADTN）或中脑被盖区受损的大鼠的乳头体内侧核（MMN）进行电刺激；2）对扣带回后皮质（RC）受损的大鼠的ADTN进行电刺激。在ADTN或RC受损的大鼠中对MMN进行双侧刺激会使血浆皮质酮浓度升高。在RC受损的动物中，ADTN刺激后的血浆皮质酮值高于刺激前。考虑到对完整大鼠的MMN或ADTN进行电刺激会使血浆皮质酮浓度降低，这些研究表明，只有当MMN和ADTN的投射区域保持完整时，它们才会对肾上腺皮质活动产生抑制作用。