新型水飞蓟宾类似物的合成与抗氧化性能评价

Synthesis and antioxidant evaluation of novel silybin analogues.

作者信息

Yang Leixiang, Gong Jingxu, Wang Feng, Zhang Yongmin, Wang Yanguang, Hao Xiaojiang, Wu Xiumei, Bai Hua, Stöckigt Joachim, Zhao Yu

机构信息

Department of Traditional Chinese Medicine and Natural Drug Research, College of Pharmaceutical Sciences, Zhejiang University, 353 Yan an Road, Hangzhou 310031, PR China.

出版信息

J Enzyme Inhib Med Chem. 2006 Aug;21(4):399-404. doi: 10.1080/14756360600682152.

DOI:10.1080/14756360600682152

PMID:17059172

Abstract

In this work, we evaluated the antioxidant properties of the eight novel silybin analogues for their capacity to scavenge free radicals including superoxide anion radicals and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals in vitro. Compound 7d demonstrated an excellent antioxidant effect in scavenging superoxide anion free radical with an IC50 value of 26.5 microM, while the IC50 of quercetin (the reference compound) was 38.1 microM. Compounds 7b, 7e, 7h showed certain scavenging activities for both types of free radicals.

摘要

在本研究中，我们评估了八种新型水飞蓟宾类似物的抗氧化性能，考察了它们在体外清除自由基（包括超氧阴离子自由基和1,1-二苯基-2-苦基肼自由基（DPPH））的能力。化合物7d在清除超氧阴离子自由基方面表现出优异的抗氧化效果，IC50值为26.5微摩尔，而槲皮素（参比化合物）的IC50为38.1微摩尔。化合物7b、7e、7h对两种自由基均表现出一定的清除活性。