某些噻唑基噻唑烷-2,4-二酮化合物对超氧自由基、羟基自由基和DPPH自由基的清除能力。

Scavenging capacities of some thiazolyl thiazolidine-2,4-dione compounds on superoxide radical, hydroxyl radical, and DPPH radical.

作者信息

Kruk Irena, Bozdağ-Dündar Oya, Ceylan-Unlüsoy Meltem, Ertan Rahmiye, Aboul-Enein Hassan Y, Michalska Teresa

机构信息

Institute of Physics, Szczecin University of Technology, Al. Piastów 48/49, 70-311 Szczecin, Poland.

出版信息

Luminescence. 2009 Jul-Aug;24(4):230-5. doi: 10.1002/bio.1105.

DOI:10.1002/bio.1105

PMID:19253274

Abstract

The scavenging effects of eighteen thiazolyl thiazolidine-2,4-dione compounds (TTCs) on superoxide radical ( (-) () ) (2), hydroxyl radical HO(), and 1,1-diphenyl-2-picrylhydrazyl (DPPH()) radical were evaluated by the chemiluminescence technique, electron spin resonance spectrometry (ESR) and visible spectrophotometry, respectively. The examined compounds were shown to have 27-59% ( (-) () ) (2) scavenging ability, 19-69% HO() scavenging activity and 2-32% DPPH() scavenging ability. This property of the tested compound seems to be important in the prevention of various diseases of free radicals etiology.

摘要

通过化学发光技术、电子自旋共振光谱法（ESR）和可见分光光度法，分别评估了18种噻唑基噻唑烷-2,4-二酮化合物（TTCs）对超氧阴离子自由基（(-)）(2)、羟基自由基HO和1,1-二苯基-2-苦基肼自由基（DPPH*）的清除作用。所检测的化合物显示出具有27%-59%的(-)清除能力、19%-69%的HO清除活性和2%-32%的DPPH*清除能力。受试化合物的这一特性在预防各种自由基病因引起的疾病中似乎很重要。