多核苷酸。XXXII。关于含8,2'-S-环腺苷酸的寡核苷酸合成的进一步研究。
Polynucleotides. XXXII. Further studies on the synthesis of oligonucleotides containing 8,2'-S-cycloadenosine.
作者信息
Ikehara M, Tezuka T
出版信息
Nucleic Acids Res. 1975 Sep;2(9):1539-50. doi: 10.1093/nar/2.9.1539.
Abstract
A dinucleoside monophosphate, 8,2'-anhydro-8-mercapto-9-beta-D-arabinofuranosyladenine phosphoryl-(3'-5')-inosine (AspI) was synthesized by the condensation of protected 8-mercapto-adenosine 2',3'-cyclic phosphate and 2',3'-isopropylideneinosine with diphenylphosphorochloridate. 8-Mercaptoadenosine 2',3'-cyclic phosphate was polymerized by using tetraphenyl pyrophosphate as the condensing reagent. As oligonucleotides, thus obtained, contained some uncyclized 8-mercaptoadenosine residues and were cleaved at these sites with 0.3N KOH. As 5'-phosphate was synthesized and polymerized with DCC to give oligonucleotides with chain lengths 2 to 9.
摘要
一种二核苷单磷酸，8,2'-脱水-8-巯基-9-β-D-阿拉伯呋喃糖基腺嘌呤磷酸-(3'-5')-肌苷（AspI），是通过将受保护的8-巯基腺苷2',3'-环磷酸酯和2',3'-异丙叉肌苷与二苯基磷酰氯缩合而成。8-巯基腺苷2',3'-环磷酸酯以四苯基焦磷酸酯作为缩合试剂进行聚合。如此获得的寡核苷酸含有一些未环化的8-巯基腺苷残基，并在这些位点被0.3N氢氧化钾裂解。合成5'-磷酸并与二环己基碳二亚胺聚合，得到链长为2至9的寡核苷酸。
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