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多核苷酸。XXXII。关于含8,2'-S-环腺苷酸的寡核苷酸合成的进一步研究。

Polynucleotides. XXXII. Further studies on the synthesis of oligonucleotides containing 8,2'-S-cycloadenosine.

作者信息

Ikehara M, Tezuka T

出版信息

Nucleic Acids Res. 1975 Sep;2(9):1539-50. doi: 10.1093/nar/2.9.1539.

DOI:10.1093/nar/2.9.1539
PMID:170595
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC343521/
Abstract

A dinucleoside monophosphate, 8,2'-anhydro-8-mercapto-9-beta-D-arabinofuranosyladenine phosphoryl-(3'-5')-inosine (AspI) was synthesized by the condensation of protected 8-mercapto-adenosine 2',3'-cyclic phosphate and 2',3'-isopropylideneinosine with diphenylphosphorochloridate. 8-Mercaptoadenosine 2',3'-cyclic phosphate was polymerized by using tetraphenyl pyrophosphate as the condensing reagent. As oligonucleotides, thus obtained, contained some uncyclized 8-mercaptoadenosine residues and were cleaved at these sites with 0.3N KOH. As 5'-phosphate was synthesized and polymerized with DCC to give oligonucleotides with chain lengths 2 to 9.

摘要

一种二核苷单磷酸，8,2'-脱水-8-巯基-9-β-D-阿拉伯呋喃糖基腺嘌呤磷酸-(3'-5')-肌苷（AspI），是通过将受保护的8-巯基腺苷2',3'-环磷酸酯和2',3'-异丙叉肌苷与二苯基磷酰氯缩合而成。8-巯基腺苷2',3'-环磷酸酯以四苯基焦磷酸酯作为缩合试剂进行聚合。如此获得的寡核苷酸含有一些未环化的8-巯基腺苷残基，并在这些位点被0.3N氢氧化钾裂解。合成5'-磷酸并与二环己基碳二亚胺聚合，得到链长为2至9的寡核苷酸。

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本文引用的文献

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THE EFFECT OF UREA, FORMAMIDE, AND GLYCOLS ON THE SECONDARY BINDING FORCES IN THE ION-EXCHANGE CHROMATOGRAPHY OF POLYNUCLEOTIDES OF DEAE-CELLULOSE.尿素、甲酰胺和二醇对DEAE - 纤维素多核苷酸离子交换色谱中二级结合力的影响
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Arabinonucleotides. I. A study of the formation of 3,-arabinonucleotidyl esters by the conversion of an internucleotide linkage.阿拉伯核糖核苷酸。I. 通过核苷酸间连接的转化对3'-阿拉伯核糖核苷酸酯形成的研究。
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Synthesis and properties of the dinucleoside monophosphate of adenine 8-thiocyclonucleoside.腺嘌呤8-硫代环核苷单磷酸二核苷的合成与性质
J Am Chem Soc. 1972 Jul 26;94(15):5480-6. doi: 10.1021/ja00770a053.
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Synthesis of cyclouridine oligonucleotides forming a double stranded complex of left-handedness with cycloadenosine oligonucleotides.形成与环腺苷酸寡核苷酸呈左手性双链复合物的环尿苷酸寡核苷酸的合成。
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9
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