Lian Zhen-Qiang, Yang Ming-Tian, Hou Jing-Hui, Luo Rong-Zhen, Wang Xi, Tang Jun
State Key Laboratory of Oncology in South China, Guangzhou, Guangdong, 510060, P. R. China.
Ai Zheng. 2006 Oct;25(10):1291-5.
BACKGROUND & OBJECTIVE: Many researches suggest that CD44v6 is associated with the occurrence, invasion, and metastasis of breast cancer. However the reports about the relationship between CD44v6 expression and the prognosis of breast cancer are conflicting. This study was to investigate the expression of CD44v6 and its correlation to clinicopathologic characteristics and prognosis of breast cancer.
CD44v6 expression in 84 specimens of breast cancer and 20 specimens of para-tumor breast tissues was detected by SP immunohistochemistry. COX proportional hazards model was used to analyze the prognosis.
The positive rate of CD44v6 in the epithelial cells of breast cancer was significantly higher than that in para-tumor breast tissues (78.6% vs. 5.0%, P<0.05). The expression of CD44v6 was closely correlated to TNM stage, tumor size, and lymph node metastasis (P<0.05). The median follow-up period was 60 months. The overall survival rate was significantly higher in CD44v6-negative group than in CD44v6-positive group (P<0.05). The survival curve had a tendency to decline with the stronger expression of CD44v6. Cox model revealed that ER, TNM stage, and CD44v6 were independent prognostic factors of breast cancer.
CD44v6 is highly expressed in breast cancer, and positively correlated to TNM stage, tumor size, and lymph node metastasis. CD44v6 is an independent prognostic factor of breast cancer.
许多研究表明，CD44v6与乳腺癌的发生、侵袭和转移相关。然而，关于CD44v6表达与乳腺癌预后关系的报道相互矛盾。本研究旨在探讨CD44v6在乳腺癌中的表达及其与临床病理特征和预后的相关性。
采用SP免疫组化法检测84例乳腺癌标本和20例癌旁乳腺组织标本中CD44v6的表达。采用COX比例风险模型分析预后。
乳腺癌上皮细胞中CD44v6的阳性率显著高于癌旁乳腺组织（78.6%比5.0%，P<0.05）。CD44v6的表达与TNM分期、肿瘤大小及淋巴结转移密切相关（P<0.05）。中位随访期为60个月。CD44v6阴性组的总生存率显著高于CD44v6阳性组（P<0.05）。生存曲线随CD44v6表达增强有下降趋势。Cox模型显示，雌激素受体（ER）、TNM分期和CD44v6是乳腺癌的独立预后因素。
CD44v6在乳腺癌中高表达，且与TNM分期、肿瘤大小及淋巴结转移呈正相关。CD44v6是乳腺癌的独立预后因素。
