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[益生菌——我们应该改变袋状结肠炎的治疗策略吗?]

[Probiotics--should we change the treatment strategy for pouchitis?].

作者信息

Klinge Lone Gabriels, Kjeldsen Jens

机构信息

Odense Universitetshospital, Medicinsk Gastroenterologisk Afdeling S, Odense C.

出版信息

Ugeskr Laeger. 2006 Oct 9;168(41):3516-8.

Abstract

Pouchitis is an idiopathic inflammatory bowel disease, which occurs in up to 50% of patients operated on for ulcerative colitis with ileal pouch-anal anastomosis (IPAA). Treatment of pouchitis is still to a large extent empirical, but recently more randomized, double-blind placebo-controlled trials have been conducted. This article reviews the possible treatments for pouchitis, focusing especially on treatment with probiotics, which seem to be a new and promising alternative to antibiotics. We are currently doing clinical trials to determine whether a probiotic is an effective treatment for chronic inflammatory bowel disease.

摘要

储袋炎是一种特发性炎症性肠病,在接受回肠储袋肛管吻合术(IPAA)治疗溃疡性结肠炎的患者中,发病率高达50%。储袋炎的治疗在很大程度上仍基于经验,但最近已经开展了更多随机、双盲、安慰剂对照试验。本文综述了储袋炎可能的治疗方法,尤其着重于益生菌治疗,这似乎是一种替代抗生素的新的、有前景的方法。我们目前正在进行临床试验,以确定益生菌是否是治疗慢性炎症性肠病的有效方法。

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