嗜酸性粒细胞性卵巢炎：与粪类圆线虫血清学阳性及伊维菌素的临床反应相关

Eosinophilic oophoritis: association with positive Strongyloides stercoralis serology and clinical response to ivermectin.

作者信息

Butterfield Joseph H, Kephart Gail M, Frankson J L

机构信息

Division of Allergic Diseases, Mayo Clinic, Rochester, Minnesota 55905, USA.

出版信息

J Pediatr Adolesc Gynecol. 2006 Oct;19(5):329-32. doi: 10.1016/j.jpag.2006.06.001.

DOI:10.1016/j.jpag.2006.06.001

PMID:17060015

Abstract

BACKGROUND

Localized eosinophilic infiltration causing ovarian dysfunction is an unusual clinical problem.

CASE

We report a 16-year-old girl with abdominal pain, ovarian cysts, and biopsy-proven eosinophilic oophoritis, which resulted in right oophorectomy. Subsequently, a large cyst developed in the left ovary, causing abdominal pain that was worse at the time of her menses, and biopsy again showed numerous eosinophilic microabscesses. Unexpectedly, a parasite serology test to Strongyloides stercoralis was positive, although stool tests for ova and parasites were negative and the total IgE and total eosinophil count were normal. After treatment with ivermectin, the patient's abdominal pain resolved, the serologic antibody titers to S stercoralis returned to normal, and subsequent ultrasonographic evaluations showed involution of the large cyst in the remaining ovary.

CONCLUSION

Eosinophilic oophoritis is a new disorder of localized tissue eosinophilia.

摘要

背景

局部嗜酸性粒细胞浸润导致卵巢功能障碍是一个不寻常的临床问题。

病例

我们报告一名16岁女孩，有腹痛、卵巢囊肿，活检证实为嗜酸性粒细胞性卵巢炎，这导致了右侧卵巢切除术。随后，左侧卵巢出现一个大囊肿，引起腹痛，在月经期间加重，再次活检显示有大量嗜酸性微脓肿。出乎意料的是，粪类圆线虫的寄生虫血清学检测呈阳性，尽管粪便虫卵和寄生虫检测为阴性，且总IgE和嗜酸性粒细胞总数正常。用伊维菌素治疗后，患者的腹痛缓解，粪类圆线虫的血清学抗体滴度恢复正常，随后的超声检查显示剩余卵巢中的大囊肿消退。