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病例报告:皮下注射伊维菌素治疗类圆线虫重度感染失败

Case report: failure of subcutaneous ivermectin in treating Strongyloides hyperinfection.

作者信息

Leung Victor, Al-Rawahi Ghada N, Grant Jennifer, Fleckenstein Lawrence, Bowie William

机构信息

Department of Internal Medicine, University of British Columbia, Vancouver General Hospital, Vancouver, British Columbia, Canada.

出版信息

Am J Trop Med Hyg. 2008 Dec;79(6):853-5.

PMID:19052292
Abstract

A man with Escherichia coli meningitis and bacteremia, while on dexamethasone, developed Strongyloides hyperinfection syndrome and died despite salvage therapy with subcutaneous ivermectin. We report the first documented total and free levels of subcutaneous ivermectin used for therapy.

摘要

一名患有大肠杆菌脑膜炎和菌血症的男子在接受地塞米松治疗时,出现了类圆线虫重度感染综合征,尽管接受了皮下注射伊维菌素的挽救治疗,仍不幸死亡。我们报告了首例有记录的用于治疗的皮下伊维菌素的总水平和游离水平。

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Case report: failure of subcutaneous ivermectin in treating Strongyloides hyperinfection.病例报告:皮下注射伊维菌素治疗类圆线虫重度感染失败
Am J Trop Med Hyg. 2008 Dec;79(6):853-5.
2
Treatment of human disseminated strongyloidiasis with a parenteral veterinary formulation of ivermectin.用伊维菌素的一种肠胃外兽用制剂治疗人类播散性类圆线虫病。
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Serum ivermectin levels after enteral and subcutaneous administration for Strongyloides hyperinfection: a case report.肠内和皮下给药治疗类圆线虫重度感染后的血清伊维菌素水平:病例报告
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[Subcutaneous ivermectin in disseminated strongyloidiasis: A veterinary preparation authorised for human use].[皮下注射伊维菌素治疗播散性类圆线虫病:一种获批准用于人类的兽用制剂]
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Salvage treatment of disseminated strongyloidiasis in an immunocompromised patient: therapy success with subcutaneous ivermectin.免疫功能低下患者播散性旋毛虫病的挽救治疗:皮下伊维菌素治疗成功。
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Fatal outcome of a hyperinfection syndrome despite successful eradication of Strongyloides with subcutaneous ivermectin.尽管皮下注射伊维菌素成功根除了类圆线虫,但仍出现了重度感染综合征的致命结局。
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引用本文的文献

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Case Report: Ivermectin and Albendazole Plasma Concentrations in a Patient with Disseminated Strongyloidiasis on Extracorporeal Membrane Oxygenation and Continuous Renal Replacement Therapy.病例报告:在接受体外膜肺氧合和持续肾脏替代治疗的患者中,伊维菌素和阿苯达唑的血浆浓度。
Am J Trop Med Hyg. 2018 Nov;99(5):1194-1197. doi: 10.4269/ajtmh.18-0487.
2
Successful use of subcutaneous ivermectin for the treatment of hyperinfection in the setting of small bowel obstruction and paralytic ileus in the immunocompromised population.在免疫功能低下人群中,成功使用皮下注射伊维菌素治疗小肠梗阻和麻痹性肠梗阻情况下的重度感染。
BMJ Case Rep. 2018 Jun 4;2018:bcr-2017-223138. doi: 10.1136/bcr-2017-223138.
3
CATMAT statement on disseminated strongyloidiasis: Prevention, assessment and management guidelines.
CATMAT关于播散性类圆线虫病的声明:预防、评估和管理指南。
Can Commun Dis Rep. 2016 Jan 7;42(1):12-19. doi: 10.14745/ccdr.v42i01a03.
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Strongyloides stercoralis hyperinfection syndrome: a case series and a review of the literature.粪类圆线虫超感染综合征:病例系列及文献综述
Infection. 2015 Dec;43(6):691-8. doi: 10.1007/s15010-015-0799-1. Epub 2015 May 26.
5
Failure of ivermectin per rectum to achieve clinically meaningful serum levels in two cases of Strongyloides hyperinfection.两例类圆线虫重度感染患者经直肠给予伊维菌素后,未能达到具有临床意义的血清水平。
Am J Trop Med Hyg. 2015 Jul;93(1):94-6. doi: 10.4269/ajtmh.15-0077. Epub 2015 Apr 27.
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Severe strongyloidiasis: a systematic review of case reports.严重的类圆线虫病:病例报告的系统评价。
BMC Infect Dis. 2013 Feb 8;13:78. doi: 10.1186/1471-2334-13-78.
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Non-oral treatment with ivermectin for disseminated strongyloidiasis.伊维菌素非口服治疗播散性旋毛虫病。
Am J Trop Med Hyg. 2010 Oct;83(4):879-83. doi: 10.4269/ajtmh.2010.10-0258.