己酮可可碱对体外循环中的细胞因子反应有影响。
Pentoxifylline affects cytokine reaction in cardiopulmonary bypass.
作者信息
Iskesen Ihsan, Saribulbul Osman, Cerrahoglu Mustafa, Onur Ece, Destan Bugra, Sirin Bekir Hayrettin
机构信息
Department of Cardiovascular Surgery, Celal Bayar University School of Medicine, Manisa, Turkey.
出版信息
Heart Surg Forum. 2006;9(6):E883-7. doi: 10.1532/HSF98.20061090.
BACKGROUND
Cardiac surgery is associated with an inflammatory response that may cause myocardial dysfunction after cardiopulmonary bypass. We examined the efficacy of pentoxifylline to attenuate the cardiopulmonary bypass-induced inflammatory response during heart operations.
METHODS
In a prospective, randomized study, 30 patients undergoing coronary artery bypass graft surgery received either pentoxifylline (group P, n = 15) (continuous infusion of 1.5 mg/kg per hour during operation) or not (group C [control], n = 15). Blood samples for measurements of tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, IL-8, and IL-10 were taken from the arterial line in both groups at 5 different time points.
RESULTS
TNF-alpha, IL-6, and IL-8 plasma levels increased in both groups after cardiopulmonary bypass, with a higher increase in the control group (P < .05).
CONCLUSIONS
Our results indicate that pentoxifylline infusion during cardiac surgery inhibits the proinflammatory cytokine release caused by cardiopulmonary bypass.
背景
心脏手术会引发炎症反应，这可能导致体外循环后心肌功能障碍。我们研究了己酮可可碱在心脏手术期间减轻体外循环诱导的炎症反应的疗效。
方法
在一项前瞻性随机研究中，30例行冠状动脉旁路移植术的患者，其中15例接受己酮可可碱治疗（P组）（术中持续输注1.5mg/kg每小时），另外15例不接受治疗（C组[对照组]）。两组均在5个不同时间点从动脉导管采集血样，用于检测肿瘤坏死因子（TNF）-α、白细胞介素（IL）-6、IL-8和IL-10。
结果
体外循环后两组患者的TNF-α、IL-6和IL-8血浆水平均升高，对照组升高幅度更大（P<0.05）。
结论
我们的结果表明，心脏手术期间输注己酮可可碱可抑制体外循环引起的促炎细胞因子释放。
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