妊娠期奥卡西平血药浓度：一项针对癫痫患者的回顾性研究
Oxcarbazepine concentrations during pregnancy: a retrospective study in patients with epilepsy.
作者信息
Christensen Jakob, Sabers Anne, Sidenius Per
机构信息
Department of Clinical Pharmacology, Aarhus University Hospital, Norrebrogade 44, DK-8000 Aarhus C, Denmark.
出版信息
Neurology. 2006 Oct 24;67(8):1497-9. doi: 10.1212/01.wnl.0000240047.11166.0e.
We assessed the concentration of the oxcarbazepine metabolite 10-hydroxycarbazepine (MHD) in nine pregnancies among seven women before, during, and after pregnancy. The mean dose-corrected concentration of MHD was decreased during pregnancy (analysis of variance, p = 0.0016), being 72% (SD = 13%) in the first trimester, 74% (SD = 17%) in the second trimester, 64% (SD = 6%) in the third trimester, and 108% (SD = 18%) after pregnancy vs the dose-corrected concentration before pregnancy.
我们评估了7名女性9次妊娠中，在妊娠前、妊娠期间及妊娠后奥卡西平代谢物10-羟基卡马西平（MHD）的浓度。与妊娠前经剂量校正后的浓度相比，妊娠期间MHD的平均经剂量校正浓度降低（方差分析，p = 0.0016），妊娠早期为72%（标准差 = 13%），妊娠中期为74%（标准差 = 17%），妊娠晚期为64%（标准差 = 6%），妊娠后为108%（标准差 = 18%）。
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