Tuncel Deniz, Ozbek Ayda Ertugrul, Demirpolat Gülen, Karabiber Hamza
Department of Neurology, Kahramanmaras Sutcu Imam University, Kahramanmaras, Turkey.
Jpn J Infect Dis. 2006 Oct;59(5):317-9.
Subacute sclerosing panencephalitis (SSPE) can show variations in its clinical course. Typical initial symptoms consist of intellectual decline, deterioration in school performance, and myoclonic jerks. Atypical forms of presentation such as generalized seizures and acute or subacute coma can be observed rarely. This report describes a 5-year-old boy with an atypical feature of SSPE, generalized seizures. For 1 month his only symptom was seizures, followed by personality and behavioral changes and myoclonic jerks. A diagnosis of SSPE was made based on the boy's history of measles, characteristic electroencephalogram changes and compatible magnetic resonance, and elevated anti-measles antibody titers in the cerebrospinal fluid and serum. The case presented in this article is a good example of SSPE in which, at early stages, some of the signs and symptoms can lead to an erroneous diagnosis.
亚急性硬化性全脑炎（SSPE）的临床病程可能会有所不同。典型的初始症状包括智力衰退、学业成绩下降和肌阵挛性抽搐。很少能观察到非典型的表现形式，如全身性癫痫发作以及急性或亚急性昏迷。本报告描述了一名5岁男孩，具有SSPE的非典型特征——全身性癫痫发作。在1个月的时间里，他唯一的症状就是癫痫发作，随后出现了性格和行为改变以及肌阵挛性抽搐。根据该男孩的麻疹病史、特征性脑电图变化、相符的磁共振成像以及脑脊液和血清中抗麻疹抗体滴度升高，做出了SSPE的诊断。本文所呈现的病例是SSPE的一个典型例子，即在早期阶段，一些体征和症状可能会导致错误的诊断。
