Hergüner M Ozlem, Altunbaşak Sakir, Baytok Vildan
Department of Pediatric Neurology, Cukurova University Faculty of Medicine, Adana, Turkey.
Turk J Pediatr. 2007 Oct-Dec;49(4):422-5.
Subacute sclerosing panencephalitis (SSPE) usually begins insidiously and follows a subacute course with relentless but slow progression to death. In recent years, however, patients with acute or fulminant course were reported. In this article, we report on three patients (2 girls, 1 boy) with SSPE who developed an acute and fulminant course. Subacute sclerosing panencephalitis may be seen with more atypical symptoms and more acute and fulminant courses due to various undetermined reasons. Early diagnosis is very important for the effectiveness of treatment. Children presenting with acute or subacute neurologic symptoms should be examined for SSPE, especially if they have no risk factors for hereditary neurodegenerative/ neurometabolic diseases, and it is more important if those children were not vaccinated or were infected with measles.
亚急性硬化性全脑炎（SSPE）通常起病隐匿，呈亚急性病程，病情持续进展但速度缓慢，最终导致死亡。然而，近年来有报道称出现了急性或暴发性病程的患者。在本文中，我们报告了3例（2名女孩，1名男孩）患亚急性硬化性全脑炎且病程呈急性和暴发性的患者。由于各种尚未明确的原因，亚急性硬化性全脑炎可能会出现更多非典型症状以及更急性和暴发性的病程。早期诊断对治疗效果非常重要。出现急性或亚急性神经症状的儿童应接受亚急性硬化性全脑炎检查，尤其是那些没有遗传性神经退行性/神经代谢性疾病风险因素的儿童，如果这些儿童未接种疫苗或感染过麻疹则更为重要。
