Lee Seuk Hyun, Kim Kyung-Ah, Lee June Sung, Oh Dong Hoon, Bae Won Ki, Kim Nam-Hoon, Moon Young Soo, Kim Han Seong
Department of Internal Medicine, Ilsan Paik Hospital, Inje University College of Medicine, Ilsan-Gu, Goyang, Korea.
Korean J Gastroenterol. 2006 Oct;48(4):277-80.
Primary hepatic neuroendocrine cell carcinoma is a very rare tumor. We experienced a 75-year-old woman with primary hepatic neuroendocrine carcinoma presenting with pyogenic liver abscess. Abdominal CT scan revealed a multiseptated liver abscess and an enlarged lymph node in portocaval portion. We performed percutaneous drainage of the liver abscess, but the amount of drained pus did not decrease after 20 days. The follow-up abdominal CT scan showed that the cystic portion of liver abscess had been replaced by the solid tumor. Microscopic examination of the tumor tissue showed nests of epithelial cells with uniform round hyperchromatic nuclei and high nuclear to cytoplasmic ratio. Immunohistochemical staining was strongly positive for synaptophysin and chromogranin A.
原发性肝神经内分泌细胞癌是一种非常罕见的肿瘤。我们遇到一名75岁女性,患有原发性肝神经内分泌癌并伴有肝脓肿。腹部CT扫描显示肝内有多个分隔的脓肿以及门腔间隙淋巴结肿大。我们对肝脓肿进行了经皮引流,但20天后引流的脓液量并未减少。后续腹部CT扫描显示肝脓肿的囊性部分已被实性肿瘤取代。肿瘤组织的显微镜检查显示上皮细胞巢,细胞核均匀呈圆形,染色质深,核质比高。免疫组化染色突触素和嗜铬粒蛋白A呈强阳性。