Boncler Magdalena, Luzak Bogusława, Watala Cezary
Zakład Zaburzeń Krzepniecia Krwi, Uniwersytet Medyczny w Łodzi, Łódz, Poland.
Postepy Hig Med Dosw (Online). 2006;60:538-46.
C-reactive protein (CRP), formerly considered solely an excellent biomarker of inflammation, is now viewed as a direct contributor in atherosclerosis. With the advent of high-sensitivity assays for determining CRP, this protein has emerged as one of the most powerful independent predictors of cardiovascular disease. CRP level, which significantly increases in acute coronary syndromes, has a prognostic value in cardiovascular risk not only in patients with cardiovascular complications, but also in apparently healthy individuals. The in vivo mechanisms of CRP as a mediator of the inflammatory state and thrombotic complications are continuing to be unraveled. Here we focused on the role of C-reactive protein in the pathophysiology of atherosclerosis, including the potential mechanisms of CRP's action in the circulation, as well as the potential contribution of genetic variations within the CRP gene in the pathophysiology of vascular complications.
C反应蛋白（CRP），以前仅被视为炎症的一种优秀生物标志物，现在被认为是动脉粥样硬化的直接促成因素。随着用于测定CRP的高灵敏度检测方法的出现，这种蛋白质已成为心血管疾病最强大的独立预测指标之一。CRP水平在急性冠状动脉综合征中显著升高，不仅在有心血管并发症的患者中，而且在看似健康的个体中，对心血管风险都具有预后价值。CRP作为炎症状态和血栓形成并发症介质的体内机制仍在不断被揭示。在这里，我们重点关注C反应蛋白在动脉粥样硬化病理生理学中的作用，包括CRP在循环中的潜在作用机制，以及CRP基因内基因变异在血管并发症病理生理学中的潜在贡献。
