Sparmann Anke, van Lohuizen Maarten
Division of Molecular Genetics and Centre for Biomedical Genetics, The Netherlands Cancer Institute, Plesmanlaan 121, 1066CX Amsterdam, The Netherlands.
Nat Rev Cancer. 2006 Nov;6(11):846-56. doi: 10.1038/nrc1991.
Polycomb group (PcG) proteins are epigenetic gene silencers that are implicated in neoplastic development. Their oncogenic function might be associated with their well-established role in the maintenance of embryonic and adult stem cells. In this review, we discuss new insights into the possible mechanisms by which PcGs regulate cellular identity, and speculate how these functions might be relevant during tumorigenesis.
多梳蛋白家族（PcG）是一类表观遗传基因沉默因子，与肿瘤发生发展有关。它们的致癌功能可能与其在维持胚胎干细胞和成年干细胞方面已确立的作用相关。在本综述中，我们讨论了关于PcG调控细胞特性可能机制的新见解，并推测这些功能在肿瘤发生过程中可能如何发挥作用。
