乙酰化介导的生物调控与癌症的表观遗传学后果

Acetylation-Mediated Epigenetic Consequences for Biological Control and Cancer.

作者信息

Fritz Andrew J, McKay Kyle T, Greenyer Haley W, Pacht Emory, Toor Rabail H, Ullah Rahim, Del Porto Jackson R, Person Abigail G, Korzec Sadie J, Bright Kathleen E, Brzoza Genevieve, Heath Jessica L, Ghule Prachi N, Gordon Jonathan A R, Van Wijnen Andre J, Frietze Seth E, Glass Karen C, Lian Jane B, Stein Janet L, Stein Gary S

机构信息

Department of Biochemistry, University of Vermont, Burlington, VT, USA.

University of Vermont Cancer Center, University of Vermont, Burlington, VT, USA.

出版信息

Results Probl Cell Differ. 2025;75:25-69. doi: 10.1007/978-3-031-91459-1_2.

DOI:10.1007/978-3-031-91459-1_2

PMID:40593206

Abstract

Acetylation of histones epigenetically mediates transcriptional dynamics of gene activation and suppression in response to physiological regulatory signals. The acetylated states of histone proteins define the activities of gene promoter and enhancer elements by contributing to competency for regulatory protein interactions and control of chromatin organization including higher-order inter and intra-chromosomal interactions. Cell transformation and tumor progression are associated with and functionally related to histone acetylation. Targeting the regulatory machinery for histone acetylation provides treatment options for cancer-compromised gene expression with specificity and reduced off-target consequences.

摘要

组蛋白的乙酰化通过响应生理调节信号，在表观遗传上介导基因激活和抑制的转录动力学。组蛋白的乙酰化状态通过促进调节蛋白相互作用的能力以及控制染色质组织（包括高阶染色体间和染色体内相互作用）来定义基因启动子和增强子元件的活性。细胞转化和肿瘤进展与组蛋白乙酰化相关且在功能上与之相关。靶向组蛋白乙酰化的调节机制为癌症相关基因表达受损提供了具有特异性且脱靶后果降低的治疗选择。