Konoplia E F, Luksha G L, Detinkin O N, Zhitkovich A V, Gavrilin M A, Montik V I, Fil'chenkov G N
Fiziol Zh SSSR Im I M Sechenova. 1990 Sep;76(9):1224-31.
The interaction of glycocorticoids with serum transport proteins, plasma membranes and rat liver cytoplasmic receptors progressively declines during ontogenesis, reaching its minimum at 24 months of age. Glycocorticoid receptor complexes (GRCs) binding to the rat liver nuclei and their residual fractions as well as the glycocorticoid-induced initiation of RNA-synthesis also decrease with age. The GRCs are shown to be capable of association with nuclear envelope, nuclear matrix and RNA-containing nuclear fraction isolated from the rat liver. The intracellular glycocorticoid receptor recycling requires fresh synthesis of the RNA and protein.
在个体发育过程中，糖皮质激素与血清转运蛋白、质膜及大鼠肝脏细胞质受体的相互作用逐渐减弱，在24月龄时降至最低。与大鼠肝细胞核结合的糖皮质激素受体复合物（GRCs）及其残余部分，以及糖皮质激素诱导的RNA合成起始也随年龄增长而减少。研究表明，GRCs能够与从大鼠肝脏分离的核膜、核基质和含RNA的核部分结合。细胞内糖皮质激素受体的再循环需要RNA和蛋白质的重新合成。
