Konoplia E F, Luksha G L
Biokhimiia. 1989 Jul;54(7):1098-101.
The effects of various nucleotides and sodium molybdate on the activation of glucocorticoid-receptor complexes (GRC) isolated from tissue cytosol of 6- and 25-month-old rats was studied. It was shown that nucleoside triphosphates activate GRC in the livers of 6-month-old rats, the activating effect being decreased in the following order: UTP greater than or equal to ATP greater than GTP greater than or equal to CTP. Nucleoside di- and monophosphates exert a far lesser stimulating effect. These effects of nucleotides decrease with ageing. Molybdate ions exert a 3-fold effect on the activation of GRC from various rat tissues, i.e., stimulating, inhibiting and zero effects.
研究了各种核苷酸和钼酸钠对从6月龄和25月龄大鼠组织细胞质中分离出的糖皮质激素受体复合物（GRC）激活的影响。结果表明，三磷酸核苷可激活6月龄大鼠肝脏中的GRC，其激活作用按以下顺序降低：UTP≥ATP＞GTP≥CTP。二磷酸核苷和单磷酸核苷的刺激作用要小得多。核苷酸的这些作用随衰老而降低。钼酸根离子对来自不同大鼠组织的GRC激活有三倍效应，即刺激、抑制和无作用。
