Blackburn Patricia, Després Jean-Pierre, Lamarche Benoît, Tremblay Angelo, Bergeron Jean, Lemieux Isabelle, Couillard Charles
Department of Physical Activity and Health Sciences, Université du Quebec A Chicoutimi, Chicoutimi, Quebec, Canada.
Obesity (Silver Spring). 2006 Oct;14(10):1747-54. doi: 10.1038/oby.2006.201.
Abdominal obesity is associated with a fasting proinflammatory condition. However, not much is known of the potential variations in circulating inflammatory markers after food intake. The purpose of the present study was to examine postprandial changes in plasma tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, and C-reactive protein (CRP) concentrations in men and their potential associations with fat distribution and metabolic profile variables.
Thirty-eight men were given a high-fat meal in the morning after an overnight fast, and TNF-alpha, IL-6, and CRP levels were measured in plasma at 0, 4, and 8 hours after the meal. Physical and metabolic profiles were also assessed for each participant.
We observed a substantial increase in circulating IL-6 levels (p < 0.0001) after the meal. Although postprandial variations in circulating TNF-alpha levels across time failed to reach statistical significance (p = 0.02), we noted a significant decrease in plasma TNF-alpha concentrations 4 hours (-10%, p < 0.001 vs. 0 hours) after food intake. Plasma CRP levels were not affected by the fat load. We also noted that insulin-sensitive individuals displayed a less pronounced inflammatory response after food intake than insulin-resistant subjects.
Results of the present study show that consumption of a high-fat meal leads to an increase in plasma IL-6 concentrations and transient decrease in circulating TNF-alpha levels in overweight men. Our results suggest a possible role of insulin resistance in the modulation of the postprandial inflammatory response, which could, in turn, contribute to worsen the state of insulin resistance.
腹部肥胖与空腹时的促炎状态相关。然而，对于进食后循环炎症标志物的潜在变化知之甚少。本研究的目的是检测男性餐后血浆肿瘤坏死因子（TNF）-α、白细胞介素（IL）-6和C反应蛋白（CRP）浓度的变化及其与脂肪分布和代谢谱变量的潜在关联。
38名男性在禁食过夜后于早晨食用高脂餐，并在餐后0、4和8小时测量血浆中的TNF-α、IL-6和CRP水平。还对每位参与者的身体和代谢状况进行了评估。
我们观察到餐后循环IL-6水平大幅升高（p < 0.0001）。尽管循环TNF-α水平随时间的餐后变化未达到统计学显著性（p = 0.02），但我们注意到进食后4小时血浆TNF-α浓度显著下降（-10%，与0小时相比，p < 0.001）。血浆CRP水平不受脂肪负荷的影响。我们还注意到，与胰岛素抵抗的受试者相比，胰岛素敏感的个体在进食后炎症反应不那么明显。
本研究结果表明，食用高脂餐会导致超重男性血浆IL-6浓度升高，循环TNF-α水平短暂下降。我们的结果表明胰岛素抵抗可能在餐后炎症反应的调节中起作用，这反过来可能会导致胰岛素抵抗状态恶化。
