Park Hye Soon, Park Jung Yul, Yu Rina
Department of Family Medicine, Asan Medical Center, University of Ulsan College of Medicine, 388-1 Pungnap-dong, Songpa-gu, Seoul 138-736, South Korea.
Diabetes Res Clin Pract. 2005 Jul;69(1):29-35. doi: 10.1016/j.diabres.2004.11.007. Epub 2004 Dec 30.
To investigate the relationship between serum concentrations of the cytokines C-reactive protein (CRP), tumor necrosis factor (TNF)-alpha, and interleukin (IL)-6, and obesity and visceral adiposity.
A cross-sectional study of 100 Korean adults free from pre-existing inflammatory disease or cancer was performed. Body mass index (BMI), waist circumference, and serum concentrations of CRP, TNF-alpha and IL-6 were measured. In 46 obese subjects, fat mass was assessed by bioimpedance analysis and abdominal fat distribution was determined by computerized tomography scan.
Overall, serum concentrations of CRP, TNF-alpha and IL-6 were significantly correlated with weight, BMI, waist circumference, hip circumference, and waist-hip ratio. In obese subjects, CRP and IL-6 were significantly correlated with BMI, waist circumference and visceral adipose tissue. Multiple regression analysis showed that CRP was significantly associated with BMI, whereas IL-6 was significantly related with visceral adiposity in obese subjects.
The positive associations of obesity and visceral adiposity with elevated cytokine levels suggest the importance of reducing obesity and visceral adiposity to prevent elevations in cytokine levels.
研究细胞因子C反应蛋白（CRP）、肿瘤坏死因子（TNF）-α和白细胞介素（IL）-6的血清浓度与肥胖及内脏脂肪过多之间的关系。
对100名无既往炎性疾病或癌症的韩国成年人进行了一项横断面研究。测量了体重指数（BMI）、腰围以及CRP、TNF-α和IL-6的血清浓度。在46名肥胖受试者中，通过生物电阻抗分析评估脂肪量，并通过计算机断层扫描确定腹部脂肪分布。
总体而言，CRP、TNF-α和IL-6的血清浓度与体重、BMI、腰围、臀围和腰臀比显著相关。在肥胖受试者中，CRP和IL-6与BMI、腰围及内脏脂肪组织显著相关。多元回归分析表明，CRP与BMI显著相关，而在肥胖受试者中IL-6与内脏脂肪过多显著相关。
肥胖及内脏脂肪过多与细胞因子水平升高之间的正相关表明，减轻肥胖和内脏脂肪过多对于预防细胞因子水平升高具有重要意义。
