Martos-Moreno Gabriel A, Barrios Vicente, Soriano-Guillén Leandro, Argente Jesús
Department of Endocrinology, Hospital Infantil Universitario Niño Jesús, Universidad Autónoma de Madrid, E-28009 Madrid, Spain.
Eur J Endocrinol. 2006 Nov;155(5):757-61. doi: 10.1530/eje.1.02273.
To determine the effect of the initial metabolic imbalance and its restoration after insulin therapy on adiponectin and acylated ghrelin levels in children with type 1 diabetes mellitus (T1DM).
Twenty prepubertal children with newly diagnosed T1DM were prospectively studied at diagnosis and after 1 and 4 months of therapy. Body mass index (BMI) and serum levels of adiponectin, resistin, total and acylated ghrelin, leptin, tumor necrosis factor alpha (TNF-alpha), and interleukin-6 (IL-6) were determined. The control group comprised 40 healthy prepubertal children.
BMI was decreased at diagnosis, normalized at 1 month, and remained so thereafter. Adiponectin levels at diagnosis were similar to controls, increasing significantly after 1 month and normalizing at 4 months. Acylated ghrelin levels were lower at diagnosis, with a significant increase at 1 month and normalizing at 4 months. Resistin levels were normal at all time points. Leptin levels were decreased, while TNF-alpha and IL-6 were increased at diagnosis and normalized at 1 month.
These findings suggest that BMI is not the main predictor of acylated ghrelin or adiponectin levels in newly diagnosed T1DM subjects and that these peptides may play an important role in the metabolic adaptation in this disease.
确定1型糖尿病（T1DM）患儿初始代谢失衡及其胰岛素治疗后恢复对脂联素和酰化胃饥饿素水平的影响。
对20例新诊断的青春期前T1DM患儿在诊断时以及治疗1个月和4个月后进行前瞻性研究。测定体重指数（BMI）以及脂联素、抵抗素、总胃饥饿素和酰化胃饥饿素、瘦素、肿瘤坏死因子α（TNF-α）和白细胞介素-6（IL-6）的血清水平。对照组包括40例健康的青春期前儿童。
诊断时BMI降低，1个月时恢复正常，此后一直保持正常。诊断时脂联素水平与对照组相似，1个月后显著升高，4个月时恢复正常。酰化胃饥饿素水平在诊断时较低，1个月时显著升高，4个月时恢复正常。抵抗素水平在所有时间点均正常。瘦素水平降低，而TNF-α和IL-6在诊断时升高，1个月时恢复正常。
这些发现表明，BMI不是新诊断T1DM患者酰化胃饥饿素或脂联素水平的主要预测指标，并且这些肽可能在该疾病的代谢适应中起重要作用。
