Özcan Behiye, Delhanty Patric J D, Huisman Martin, Visser Jenny A, Neggers Sebastian J, van der Lely Aart Jan
Departments of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, PO Box 2040, 3000 CA, Rotterdam, The Netherlands.
Diabetol Metab Syndr. 2021 Jul 22;13(1):79. doi: 10.1186/s13098-021-00699-4.
Several studies have demonstrated suppressed levels of acylated (AG) and unacylated ghrelin (UAG) in patients with type 2 diabetes. However, the role of these hormones in type 1 diabetes has not been extensively studied. This study assessed the relationship between AG and UAG levels and body composition in patients with type 1 diabetes.
We selected eighteen patients with type 1 diabetes and divided them into two groups: non-obese (BMI < 25 kg/m) and overweight (BMI ≥ 25 kg/m). Demographics, parameters of body composition and serum parameters including AG and UAG, were assessed.
The patients with a BMI ≥ 25 kg/m were older and had a longer duration of diabetes. AG and UAG levels were not significantly different between non-obese and overweight groups (mean AG non-obese ± SD: 44.5 ± 29.4 pg/ml and mean UAG non-obese 42.4 ± 20.7 pg/ml vs mean AG overweight ± SD: 46.1 ± 29.6 pg/ml and mean UAG overweight 47.2 ± 18.2 pg/ml). AG/UAG ratios did not discriminate between these groups. There was a positive association of insuline dose/kg bodyweight with BMI (r = 0.45, p = 0.002).
Surprisingly, unlike non-diabetics and in T2D, we did not observe a difference in plasma levels of AG and UAG between normal weight and overweight adult type 1 diabetics. However, we did observe a positive correlation between BMI and insuline dose/kg bodyweight, suggesting that exogenous insulin is more important than the ghrelin system in the development of obesity in type 1 diabetes.
多项研究表明，2型糖尿病患者的酰基化胃饥饿素（AG）和去酰基化胃饥饿素（UAG）水平受到抑制。然而，这些激素在1型糖尿病中的作用尚未得到广泛研究。本研究评估了1型糖尿病患者AG和UAG水平与身体成分之间的关系。
我们选取了18例1型糖尿病患者，并将他们分为两组：非肥胖组（BMI＜25kg/m²）和超重组（BMI≥25kg/m²）。评估了人口统计学、身体成分参数以及包括AG和UAG在内的血清参数。
BMI≥25kg/m²的患者年龄更大，糖尿病病程更长。非肥胖组和超重组之间的AG和UAG水平无显著差异（非肥胖组平均AG±标准差：44.5±29.4pg/ml，非肥胖组平均UAG 42.4±20.7pg/ml；超重组平均AG±标准差：46.1±29.6pg/ml，超重组平均UAG 47.2±18.2pg/ml）。AG/UAG比值在这些组之间无鉴别作用。胰岛素剂量/千克体重与BMI呈正相关（r = 0.45，p = 0.002）。
令人惊讶的是，与非糖尿病患者和2型糖尿病患者不同，我们未观察到正常体重和超重的成年1型糖尿病患者血浆中AG和UAG水平存在差异。然而，我们确实观察到BMI与胰岛素剂量/千克体重之间存在正相关，这表明在1型糖尿病肥胖的发生发展中，外源性胰岛素比胃饥饿素系统更重要。
