Fujita Koichi, Nishizawa Hitoshi, Funahashi Tohru, Shimomura Iichiro, Shimabukuro Michio
Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Suita, Japan.
Circ J. 2006 Nov;70(11):1437-42. doi: 10.1253/circj.70.1437.
The metabolic syndrome (MetS) is a major target for prevention of atherosclerotic cardiovascular diseases and visceral fat accumulation is an underlying component of MetS. The aim of this study was to investigate the association of systemic oxidative stress with visceral fat accumulation and MetS.
The study group consisted of Japanese men (n=44; 51.2+/-11.4 years) and women (n=61; 55.4 +/-13.4 years). Urinary 8-epi-prostaglandin F2alpha (8-epi-PGF2 alpha) concentration, a biomarker of systemic oxidative stress, was significantly high in the subjects with MetS. As the urinary concentration of 8-epi-PGF2alpha increased, the number of criteria for MetS were significantly met (abdominal obesity, hypertriglyceridemia, low high-density lipoprotein-cholesterol, hypertension, and high fasting glucose). Among parameters associated with MetS, the correlation coefficient of visceral fat area (VFA) with urinary 8-epi-PGF2alpha concentration was the highest (r=0.636, p<0.0001). In non-obese subjects, the correlation coefficient of VFA with urinary 8-epi-PGF2alpha concentration was higher (r=0.728, p<0.0001), although there was no significant correlation between subcutaneous fat area and urinary 8-epi-PGF2 alpha. Stepwise multiple regression analysis identified VFA as the strongest and independent determinant of urinary 8-epi-PGF2 alpha (p<0.0001) followed by adiponectin (p=0.0212) and, high sensitive C-reactive protein (p=0.0365).
Systemic oxidative stress, as measured by urinary 8-epi-PGF2alpha , is strongly associated with visceral fat accumulation and MetS.
代谢综合征（MetS）是预防动脉粥样硬化性心血管疾病的主要目标，而内脏脂肪堆积是MetS的一个潜在组成部分。本研究的目的是调查全身氧化应激与内脏脂肪堆积及MetS之间的关联。
研究组包括日本男性（n = 44；51.2±11.4岁）和女性（n = 61；55.4±13.4岁）。尿8-表前列腺素F2α（8-epi-PGF2α）浓度是全身氧化应激的生物标志物，在患有MetS的受试者中显著升高。随着尿8-epi-PGF2α浓度的增加，符合MetS标准的数量显著增加（腹部肥胖、高甘油三酯血症、低高密度脂蛋白胆固醇、高血压和高空腹血糖）。在与MetS相关的参数中，内脏脂肪面积（VFA）与尿8-epi-PGF2α浓度的相关系数最高（r = 0.636，p < 0.0001）。在非肥胖受试者中，VFA与尿8-epi-PGF2α浓度的相关系数更高（r = 0.728，p < 0.0001），尽管皮下脂肪面积与尿8-epi-PGF2α之间无显著相关性。逐步多元回归分析确定VFA是尿8-epi-PGF2α最强且独立的决定因素（p < 0.0001），其次是脂联素（p = 0.0212）和高敏C反应蛋白（p = 0.0365）。
通过尿8-epi-PGF2α测量的全身氧化应激与内脏脂肪堆积及MetS密切相关。
