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硬膜外运动皮层刺激作为治疗晚期帕金森病的一种方法:老年医学的新视角。

Extradural motor cortex stimulation as a method to treat advanced Parkinson's disease: new perspectives in geriatric medicine.

作者信息

Benvenuti E, Cecchi F, Colombini A, Gori G

出版信息

Aging Clin Exp Res. 2006 Aug;18(4):347-8. doi: 10.1007/BF03324671.

Abstract

Motor fluctuations not controlled by pharmacological therapy are often encountered in long-term Parkinson's disease (PD). Neurosurgery treatment represented by deep brain stimulation (DBS) was considered a valid alternative to pharmacological treatment. Unfortunately this method is most effective in patients under age of 70. Recently it has been suggested that extradural motor cortex stimulation (EMCS) could be a valid cost-effective alternative to DBS to control motor symptoms in patients affected by Parkinson's disease. The relevant non-invasive surgical technique makes this treatment particularly indicated in geriatric patients. Brain atrophy, cognitive impairment, psychiatric symptoms are not an absolute contraindication to the treatment. We submitted to EMCS an outpatient afferent to our geriatric department, a woman 68 yrs old. The patient showed an improvement of 35% as measured by the Unified Parkinson Disease Rating Scale (UPDRS) scale after the surgery. If our findings will be confirmed in larger series, a new dimension will be added to the treatment of PD.

摘要

长期帕金森病(PD)患者经常会遇到药物治疗无法控制的运动波动。以深部脑刺激(DBS)为代表的神经外科治疗被认为是药物治疗的有效替代方法。不幸的是,这种方法在70岁以下的患者中最有效。最近有人提出,硬膜外运动皮层刺激(EMCS)可能是一种有效且性价比高的替代DBS的方法,用于控制帕金森病患者的运动症状。相关的非侵入性手术技术使这种治疗特别适用于老年患者。脑萎缩、认知障碍、精神症状并非该治疗的绝对禁忌证。我们对一名68岁的老年女性门诊患者进行了EMCS治疗,该患者隶属于我们的老年科。术后通过统一帕金森病评定量表(UPDRS)测量,患者改善了35%。如果我们的研究结果能在更大规模的系列研究中得到证实,帕金森病的治疗将开启新的篇章。

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