Kinoshita Y, Tajiri T, Ieiri S, Nagata K, Taguchi T, Suita S, Yamazaki K, Yoshino I, Maehara Y, Kohashi K, Yamamoto H, Oda Y, Tsuneyoshi M
Department of Pediatric Surgery, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.
Pediatr Surg Int. 2007 Jun;23(6):595-9. doi: 10.1007/s00383-006-1821-6. Epub 2006 Oct 25.
We herein describe a 4-year-old boy who after being treated for pneumonia showed an abnormal shadow at the hilus of the right lung on chest X-rays with continued inflammatory findings in his laboratory data. CT and MR investigations suggested the existence of a neoplasm at that site. An open biopsy was thus performed for a definite diagnosis. The histological findings and the expression of TPM3-ALK fusion gene confirmed a diagnosis of an inflammatory myofibroblastic tumor. A right upper and middle lobectomy including the tumor was thus performed for a complete resection. In addition to the histological diagnosis, the detection of the tumor specific fusion gene provided objective evidence in making a diagnosis.
我们在此描述一名4岁男孩，他在接受肺炎治疗后，胸部X光显示右肺门有异常阴影，实验室检查结果持续显示有炎症表现。CT和MR检查提示该部位存在肿瘤。因此进行了开放性活检以明确诊断。组织学检查结果及TPM3-ALK融合基因的表达证实诊断为炎性肌纤维母细胞瘤。因此进行了包括肿瘤在内的右上叶和中叶切除术以完整切除肿瘤。除了组织学诊断外，肿瘤特异性融合基因的检测为诊断提供了客观依据。
