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原肌球蛋白3在恶性肿瘤发生发展中的作用机制

Mechanisms of tropomyosin 3 in the development of malignant tumors.

作者信息

Chen Anjie, Li Sixin, Gui Jiandong, Zhou Hangsheng, Zhu Lijie, Mi Yuanyuan

机构信息

Department of Urology, Affiliated Hospital of Jiangnan University, 1000 Hefeng Road, Wuxi, 214122, Jiangsu Province, China.

Wuxi School of Medicine, Jiangnan University, 1800 Lihudadao, Wuxi, 214122, Jiangsu Province, China.

出版信息

Heliyon. 2024 Aug 2;10(15):e35723. doi: 10.1016/j.heliyon.2024.e35723. eCollection 2024 Aug 15.

DOI:10.1016/j.heliyon.2024.e35723
PMID:39170461
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11336884/
Abstract

Tropomyosin (TPM) is an important regulatory protein that binds to actin in fine myofilaments, playing a crucial role in the regulation of muscle contraction. TPM3, as one of four tropomyosin genes, is notably prevalent in eukaryotic cells. Traditionally, abnormal gene expression of TPM3 has been exclusively associated with myopathy. However, recent years have witnessed a surge in studies highlighting the close correlation between abnormal expression of TPM3 and the onset, progression, metastasis, and prognosis of various malignant tumors. In light of this, investigating the mechanisms underlying the pathogenetic role of TPM3 holds significant promise for early diagnosis and more effective treatment strategies. This article aims to provide an insightful review of the structural characteristics of TPM3 and its intricate role in the occurrence and development of malignant tumors.

摘要

原肌球蛋白（TPM）是一种重要的调节蛋白，它与细肌丝中的肌动蛋白结合，在肌肉收缩调节中起关键作用。TPM3作为四个原肌球蛋白基因之一，在真核细胞中显著普遍存在。传统上，TPM3的基因异常表达仅与肌病相关。然而，近年来，越来越多的研究强调了TPM3异常表达与各种恶性肿瘤的发生、发展、转移和预后之间的密切相关性。鉴于此，研究TPM3致病作用的潜在机制对于早期诊断和更有效的治疗策略具有重要意义。本文旨在对TPM3的结构特征及其在恶性肿瘤发生发展中的复杂作用进行深入综述。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ffaf/11336884/a367e7cb7808/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ffaf/11336884/5751c5fcc518/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ffaf/11336884/1ca3f89d0c5c/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ffaf/11336884/52ba3f0ece72/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ffaf/11336884/ec2f451ade9c/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ffaf/11336884/a367e7cb7808/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ffaf/11336884/5751c5fcc518/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ffaf/11336884/1ca3f89d0c5c/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ffaf/11336884/52ba3f0ece72/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ffaf/11336884/ec2f451ade9c/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ffaf/11336884/a367e7cb7808/gr5.jpg

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TPM3: a novel prognostic biomarker of cervical cancer that correlates with immune infiltration and promotes malignant behavior and .TPM3：一种新型的宫颈癌预后生物标志物，与免疫浸润相关并促进恶性行为。
Am J Cancer Res. 2023 Jul 15;13(7):3123-3139. eCollection 2023.
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LncRNA WEE2-AS1 knockdown inhibits the proliferation, migration and invasion of glioma cells via regulating miR-29b-2-5p/TPM3 axis.
LncRNA WEE2-AS1 敲低通过调控 miR-29b-2-5p/TPM3 轴抑制胶质瘤细胞的增殖、迁移和侵袭。
Oncol Res. 2022 Jul 13;29(2):105-117. doi: 10.32604/or.2022.03536. eCollection 2021.
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Biotechnol Genet Eng Rev. 2024 Dec;40(4):4238-4249. doi: 10.1080/02648725.2023.2208453. Epub 2023 May 5.
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Detection of gene fusions using next-generation sequencing for patients with malignancy in China.在中国，使用下一代测序技术对恶性肿瘤患者进行基因融合检测。
Front Cell Dev Biol. 2022 Dec 15;10:1035033. doi: 10.3389/fcell.2022.1035033. eCollection 2022.
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